| Release of anti-inflammatory mediators after mechanical trauma correlates with severity of injury and clinical outcome. | |
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MedLine Citation:
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PMID: 7474003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Excessive synthesis of proinflammatory cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta] after trauma has been correlated with poor outcome. Recently, naturally occurring inhibitors of TNF-alpha and IL-1 beta have been characterized such as soluble TNF receptors (sTNFRs) and IL-1 receptor antagonist (IL-1ra). The present study was undertaken to determine whether injury results in a rise of circulating sTNFRs and IL-1ra. If so, whether plasma levels of these anti-inflammatory mediators correlate with severity of injury and clinical outcome of these patients. Injured patients (n = 213) showed significantly increased sTNFR and IL-1ra plasma levels throughout the observation period of 14 days, compared with healthy volunteers (n = 127). Patients with severe injury (Injury Severity Score > 16 points) revealed higher levels (p < 0.05) of sTNFRs and IL-1ra than patients with minor trauma (Injury Severity Score < or = 16 points). Patients who died from injury demonstrated increased (p < 0.05) sTNFR p55 and IL-1ra plasma levels, compared with survivors. Thus, anti-inflammatory mechanisms are activated after trauma dependent on severity of injury. Because increased plasma levels of anti-inflammatory reacting proteins portended poorly for patient survival, these mediators may contribute to prediction of outcome after severe injury. |
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Authors:
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W Ertel; M Keel; M Bonaccio; U Steckholzer; H Gallati; J S Kenney; O Trentz |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of trauma Volume: 39 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-12-21 Completed Date: 1995-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 879-85; discussion 885-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytotoxicity Tests, Immunologic Enzyme-Linked Immunosorbent Assay Female Humans Injury Severity Score Interleukin 1 Receptor Antagonist Protein Interleukin-1 Male Receptors, Interleukin-1 / antagonists & inhibitors* Receptors, Tumor Necrosis Factor / analysis* Sialoglycoproteins / blood* Wounds and Injuries / blood*, mortality |
| Chemical | |
Reg. No./Substance:
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0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1; 0/Receptors, Interleukin-1; 0/Receptors, Tumor Necrosis Factor; 0/Sialoglycoproteins |
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