Document Detail

Release of adrenaline by anaphylaxis in the guinea-pig: its effect on lung lipid content.
MedLine Citation:
PMID:  239118     Owner:  NLM     Status:  MEDLINE    
The study was undertaken to discover whether the catecholamines released as a result of the stress and hypoxia of anaphylaxis were responsible for the concomitant loss of lipid from the lung. A method is described whereby the respiratory rate and volume and heart-rate of conscious sensitized guinea-pig were measured and the electrocardiogram recorded during anaphylaxis induced by aerosolized antigen. After 7 days or more, some animals were anaesthetized with pentobarbitone and respiration was artificially maintained at the level recorded in the conscious state, whilst the quantity of catecholamines liberated during anaphylaxis was assayed using an extra-corporeal blood circulation to superfuse smooth muscle preparations. In other animals of the same group, it was shown that intravenous infusion of adrenaline in a similar quantity to that detected in the circulation following anaphylaxis (0.3 mug min-(-1) for 40 min) caused losses of triglyceride and partial glycerides from the lungs. Thus, the loss of choline-containing phospholipid was attributed to the direct effects of the anaphylactic reaction on the lung tissue.
P Goadby
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  27     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  254-61     Citation Subset:  IM    
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MeSH Terms
Anaphylaxis / metabolism*,  physiopathology
Catecholamines / metabolism
Chick Embryo
Epinephrine / metabolism*,  pharmacology
Guinea Pigs
Heart Rate
Lipids / analysis*
Lung / analysis*
Muscle Tonus
Muscle, Smooth / physiopathology
Oxygen Consumption
Rectum / physiology
Stomach / physiology
Reg. No./Substance:
0/Catecholamines; 0/Lipids; 51-43-4/Epinephrine; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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