| Release dynamics of ciprofloxacin from swellable nanocarriers of poly(2-hydroxyethyl methacrylate): an in vitro study. | |
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MedLine Citation:
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PMID: 20044034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. Such systems have shown potential in releasing antibiotic drugs and to do so controllably. In the present investigation poly(2-hydroxyethyl methacrylate) nanoparticles were synthesized by suspension polymerization of 2-hydroxyethyl methacrylate and characterized by various techniques such as Fourier transform-infrared spectrometry, scanning electron microscopy, particle size analysis, and surface charge measurements. The synthesized nanoparticles were swellable in water and showed promise to function as a swelling controlled-release system. The release kinetics of drug-loaded particles was studied in phosphate-buffered saline (PBS) using ciprofloxacin as a model antibacterial drug. The chemical stability of the pure and released drug was also assessed in PBS (pH 7.4), acidic (pH 1.8), and alkaline (pH 8.6) solutions. The in vitro blood compatibility of nanoparticles was also investigated in terms of hemolysis tests. The drug-loaded nanoparticles were also examined for their antibacterial and blood-compatible behaviors. FROM THE CLINICAL EDITOR: Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. In this paper, the release kinetics, antimicrobial properties and in vitro "blood compatibility" is reported for a specific swellable polymeric nanosystem. |
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Authors:
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Raje Chouhan; Anil K Bajpai |
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Publication Detail:
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Type: Journal Article Date: 2010-01-04 |
Journal Detail:
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Title: Nanomedicine : nanotechnology, biology, and medicine Volume: 6 ISSN: 1549-9642 ISO Abbreviation: Nanomedicine Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233142 Medline TA: Nanomedicine Country: United States |
Other Details:
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Languages: eng Pagination: 453-62 Citation Subset: IM |
Affiliation:
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Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology Body Fluids / drug effects Ciprofloxacin / pharmacology* Cross-Linking Reagents / pharmacology Diffusion Drug Carriers / chemistry* Drug Stability Evaluation Studies as Topic Humans Hydrogen-Ion Concentration / drug effects Materials Testing Methacrylates / chemistry* Microbial Sensitivity Tests Microscopy, Electron, Scanning Models, Chemical Nanostructures / chemistry* Nanotechnology / methods* Particle Size Spectroscopy, Fourier Transform Infrared Surface Properties / drug effects Temperature |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cross-Linking Reagents; 0/Drug Carriers; 0/Methacrylates; 85721-33-1/Ciprofloxacin; 868-77-9/hydroxyethyl methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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