Document Detail


Relaxofon: a neuromuscular blockade monitor for patients under general anesthesia.
MedLine Citation:
PMID:  23365854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anesthesia consists of three components: unconsciousness, analgesia and neuromuscular blockade (NMB). A specific drug is administered by the anesthesiologist to control these different components. In this paper we propose a new system for monitoring the neuromuscular blockade in anesthesized patients during surgery. Neuromuscular blockade drugs are used routinely by clinicians to induce muscle relaxation in patients. However, the use of these drugs has some risks, so an adequate monitoring of the effects of these drugs is essential. This paper describes the Relaxofon, a NMB monitoring device based on phonomyography. The Relaxofon is composed of a hardware subsystem that records muscle sounds using microphones and a special circuit to filter out the noise and amplify the signal, and a software subsystem that analyses the acquired signal. We tested the ability of the system to record phonomyographic signals from the adductor pollicis and the corrugator supercilii muscles. We then performed the Bland-Altman test to compare the manual Train-of-Four ratio (a measure of the depth of muscle relaxation) calculation against the one performed by the Relaxofon. Finally, we calculated the Pearson correlation coefficient to measure the linear dependence between the two methods. Automatic Train-of-Four ratio calculations using this system showed very good agreement with manual calculations. Results from this work may ultimately lead to integration of NMB monitoring to an automated closed-loop anesthesia system.
Authors:
Mohamad Wehbe; Pierre A Mathieu; Thomas M Hemmerling
Related Documents :
14566314 - Partial rectus muscle-augmented transpositions in abduction deficiency.
23752204 - Sarcolipin trumps β-adrenergic receptor signaling as the favored mechanism for muscle-...
23888934 - Applicability of 3t body mri in assessment of nonfocal bone marrow involvement of hemat...
16814174 - Unilateral lateral rectus muscle recession and medial rectus muscle resection with or w...
7154694 - Pharmacological effects of synclisia scabrida alkaloid b on some isolated muscle prepar...
20864554 - Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-08-06     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anesthesia, General*
Female
Humans
Male
Monitoring, Physiologic / instrumentation*,  methods*
Myography / instrumentation,  methods
Neuromuscular Blockade*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An MR safe algometer to study phantom and residual limb pain.
Next Document:  Quantitative assessment of levodopa-induced dyskinesia using automated motion sensing technology.