| Relaxivity-Optimization of a PEGylated Iron Oxide-Based Negative Magnetic Resonance Contrast Agent for T2-Weighted Spin Echo Imaging. | |
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MedLine Citation:
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PMID: 22276942 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Concerning the outer sphere relaxation theory, the sensitivity of a T2 MRI contrast agent, expressed by the longitudinal relaxivity r2, depends on the diffusion length of water molecules relative to the particle size. For T2-weighted spin-echo imaging, theoretical concepts reveal three regimes regarding the r2 relaxivity depending on the nanocrystal size: the Motional Averaging Regime (MAR), the Static Dephasing Regime (SDR) and the Echo-Limiting Regime (ELR). The r2 maximum corresponds to the SDR, which represents a small size regime. To verify the theo-retical concepts and to adjust the SDR, tailor-made T2 con-trast agents were synthesized by controlled self-assembly of ultrasmall iron oxide nanocrystals (USPIOs) into rasp-berry-like nanoclusters with diameters of 30 to 200 nm using a PEG-based ligand. The results highlight an oppor-tunity to optimize the relaxivity of T2 contrast agents by tuning the cluster size of SPIO nanocrystals. |
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Authors:
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Elmar Henning Pöselt; Hauke Kloust; Ulrich Tromsdorf; Marcus Janschel; Christoph Hahn; Christoph Maßlo; Horst Weller |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: ACS nano Volume: - ISSN: 1936-086X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101313589 Medline TA: ACS Nano Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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