| Relaxin regulates endometrial structure and function in the rhesus monkey. | |
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MedLine Citation:
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PMID: 15956693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The actions of relaxin are highly species specific. The role of relaxin in human endometrial function has not been well understood because of the paucity of in vivo studies in women or in suitable primate models. A model of early human pregnancy was established in ovariectomized, steroid-primed rhesus monkeys. Relaxin exerts dramatic uterine effects in this model, including a pronounced increase in uterine weight and stimulation of endometrial angiogenesis. In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases (MMP), causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1. This results in maintenance of endometrial collagen content. The negative effects of relaxin on MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix. Relaxin also significantly inhibits endometrial levels of estrogen receptor alpha and significantly inhibits levels of progesterone isoforms B and A. The findings that relaxin stimulates new blood vessel formation while maintaining endometrial connective tissue integrity are consistent with a significant role of relaxin in the establishment and/or maintenance of early pregnancy. |
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Authors:
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Laura T Goldsmith; Gerson Weiss |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1041 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-06-15 Completed Date: 2005-10-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 110-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School of UMDNJ, Newark, NJ 07103-1709, USA. goldsmit@umdnj.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Collagen / metabolism Endometrium / anatomy & histology*, blood supply, metabolism* Female Gene Expression Regulation Humans Leukocyte Count Lymphocytes / cytology Macaca mulatta / metabolism* Matrix Metalloproteinases / metabolism Organ Specificity Receptors, G-Protein-Coupled Receptors, Peptide / metabolism Receptors, Steroid / metabolism Relaxin / biosynthesis, metabolism* Steroids / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD 22338/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, G-Protein-Coupled; 0/Receptors, Peptide; 0/Receptors, Steroid; 0/Steroids; 0/relaxin receptors; 9002-69-1/Relaxin; 9007-34-5/Collagen; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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