Document Detail


Relaxin regulates endometrial structure and function in the rhesus monkey.
MedLine Citation:
PMID:  15956693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The actions of relaxin are highly species specific. The role of relaxin in human endometrial function has not been well understood because of the paucity of in vivo studies in women or in suitable primate models. A model of early human pregnancy was established in ovariectomized, steroid-primed rhesus monkeys. Relaxin exerts dramatic uterine effects in this model, including a pronounced increase in uterine weight and stimulation of endometrial angiogenesis. In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases (MMP), causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1. This results in maintenance of endometrial collagen content. The negative effects of relaxin on MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix. Relaxin also significantly inhibits endometrial levels of estrogen receptor alpha and significantly inhibits levels of progesterone isoforms B and A. The findings that relaxin stimulates new blood vessel formation while maintaining endometrial connective tissue integrity are consistent with a significant role of relaxin in the establishment and/or maintenance of early pregnancy.
Authors:
Laura T Goldsmith; Gerson Weiss
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1041     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-15     Completed Date:  2005-10-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School of UMDNJ, Newark, NJ 07103-1709, USA. goldsmit@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Collagen / metabolism
Endometrium / anatomy & histology*,  blood supply,  metabolism*
Female
Gene Expression Regulation
Humans
Leukocyte Count
Lymphocytes / cytology
Macaca mulatta / metabolism*
Matrix Metalloproteinases / metabolism
Organ Specificity
Receptors, G-Protein-Coupled
Receptors, Peptide / metabolism
Receptors, Steroid / metabolism
Relaxin / biosynthesis,  metabolism*
Steroids / metabolism
Grant Support
ID/Acronym/Agency:
HD 22338/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, G-Protein-Coupled; 0/Receptors, Peptide; 0/Receptors, Steroid; 0/Steroids; 0/relaxin receptors; 9002-69-1/Relaxin; 9007-34-5/Collagen; EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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