Document Detail


Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow.
MedLine Citation:
PMID:  22744867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Normal pregnancy involves dramatic remodeling of the uterine vasculature, with abnormal vascular adaptations contributing to pregnancy diseases such as preeclampsia. The peptide hormone relaxin is important for the renal and systemic hemodynamic adaptations to pregnancy, and has been shown to increase arterial compliance and outward hypertrophic remodeling. Therefore, we investigated the possibility that relaxin acts on its receptor, RXFP1, to mediate uterine artery compliance in late pregnancy and increase uterine blood flow velocity in rats. RXFP1 was predominantly localized to the tunica media vascular smooth muscle cells in the uterine artery, although receptors were also detected in endothelial cells. Highest expression of Rxfp1 in the uterine artery occurred in estrus and early pregnancy. Isolated uterine arteries from late pregnant rats treated with a monoclonal antibody against circulating relaxin (MCA1) had significantly increased vessel wall stiffness compared with controls, with no reduction in wall thickness. Chronic infusion of relaxin (4 μg/h, osmotic minipump) for 5 d in nonpregnant rats significantly increased uterine artery blood flow velocity. Overall, these data demonstrate a functional role for relaxin in mediating uterine artery compliance in pregnant rats, which may be necessary to maintain adequate uterine blood flow to the uterus and placenta.
Authors:
Lenka A Vodstrcil; Marianne Tare; Jacqueline Novak; Nicoleta Dragomir; Rolando J Ramirez; Mary E Wlodek; Kirk P Conrad; Laura J Parry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-28
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  26     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2012-12-12     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4035-44     Citation Subset:  IM    
Affiliation:
Department of Zoology, The University of Melbourne, Gate 12, Royal Parade, Parkville, VIC, 3010, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Neutralizing / pharmacology
Extracellular Matrix / drug effects,  metabolism
Female
Fluorescent Antibody Technique
Humans
Immunohistochemistry
Muscle, Smooth, Vascular / drug effects,  metabolism
Pregnancy
Pregnancy, Animal
Rats
Rats, Inbred WKY
Receptors, G-Protein-Coupled / metabolism
Receptors, Peptide / metabolism
Relaxin / antagonists & inhibitors,  metabolism*
Uterine Artery / drug effects,  metabolism*
Uterus / blood supply*,  drug effects,  metabolism*
Grant Support
ID/Acronym/Agency:
UL1 TR000064/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Neutralizing; 0/Lgr7 protein, rat; 0/Receptors, G-Protein-Coupled; 0/Receptors, Peptide; 9002-69-1/Relaxin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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