| Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow. | |
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MedLine Citation:
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PMID: 22744867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal pregnancy involves dramatic remodeling of the uterine vasculature, with abnormal vascular adaptations contributing to pregnancy diseases such as preeclampsia. The peptide hormone relaxin is important for the renal and systemic hemodynamic adaptations to pregnancy, and has been shown to increase arterial compliance and outward hypertrophic remodeling. Therefore, we investigated the possibility that relaxin acts on its receptor, RXFP1, to mediate uterine artery compliance in late pregnancy and increase uterine blood flow velocity in rats. RXFP1 was predominantly localized to the tunica media vascular smooth muscle cells in the uterine artery, although receptors were also detected in endothelial cells. Highest expression of Rxfp1 in the uterine artery occurred in estrus and early pregnancy. Isolated uterine arteries from late pregnant rats treated with a monoclonal antibody against circulating relaxin (MCA1) had significantly increased vessel wall stiffness compared with controls, with no reduction in wall thickness. Chronic infusion of relaxin (4 μg/h, osmotic minipump) for 5 d in nonpregnant rats significantly increased uterine artery blood flow velocity. Overall, these data demonstrate a functional role for relaxin in mediating uterine artery compliance in pregnant rats, which may be necessary to maintain adequate uterine blood flow to the uterus and placenta. |
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Authors:
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Lenka A Vodstrcil; Marianne Tare; Jacqueline Novak; Nicoleta Dragomir; Rolando J Ramirez; Mary E Wlodek; Kirk P Conrad; Laura J Parry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-06-28 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 26 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-02 Completed Date: 2012-12-12 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 4035-44 Citation Subset: IM |
Affiliation:
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Department of Zoology, The University of Melbourne, Gate 12, Royal Parade, Parkville, VIC, 3010, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Neutralizing / pharmacology Extracellular Matrix / drug effects, metabolism Female Fluorescent Antibody Technique Humans Immunohistochemistry Muscle, Smooth, Vascular / drug effects, metabolism Pregnancy Pregnancy, Animal Rats Rats, Inbred WKY Receptors, G-Protein-Coupled / metabolism Receptors, Peptide / metabolism Relaxin / antagonists & inhibitors, metabolism* Uterine Artery / drug effects, metabolism* Uterus / blood supply*, drug effects, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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UL1 TR000064/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Neutralizing; 0/Lgr7 protein, rat; 0/Receptors, G-Protein-Coupled; 0/Receptors, Peptide; 9002-69-1/Relaxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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