Document Detail


Relaxin inhibits prostacyclin release by the rat pregnant myometrium.
MedLine Citation:
PMID:  6815714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Porcine relaxin (30 microgram/ml) when incubated with separated myometrial tissue from 20 day pregnant rats inhibited basal prostacyclin output by 50%. However, relaxin did not inhibit the increased prostacyclin output observed when myometrial tissue was incubated with the prostaglandin precursor, arachidonic acid (10 microgram/ml). When prostacyclin release was stimulated by incubation with oxytocin (10 mU/ml), however, relaxin completely inhibited the increased output. The results suggest that relaxin interferes with basal and oxytocin-stimulated prostacyclin formation in pregnant myometrial tissue by inhibiting the action of the enzyme phospholipase A2 which is responsible for liberating the precursor arachidonic acid endogenously.
Authors:
K I Williams; K E El Tahir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  24     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / pharmacology
Animals
Arachidonic Acid
Arachidonic Acids / pharmacology
Epoprostenol / pharmacology,  secretion*
Female
Kinetics
Myometrium / drug effects,  secretion*
Oxytocin / pharmacology
Platelet Aggregation / drug effects
Pregnancy
Pregnancy, Animal*
Prostaglandins / secretion*
Rats
Rats, Inbred Strains
Relaxin / pharmacology*
Swine
Uterus / secretion*
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 35121-78-9/Epoprostenol; 50-56-6/Oxytocin; 506-32-1/Arachidonic Acid; 58-64-0/Adenosine Diphosphate; 9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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