Document Detail

Relaxin has a role in establishing a renal response in pregnancy.
MedLine Citation:
PMID:  16730722     Owner:  NLM     Status:  MEDLINE    
Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9) had serial measurements of renal function made during the first trimester of pregnancy by using 24-hour creatinine clearance (CrCl) and plasma osmolality (P(osm)). All pregnancies were associated with increasing CrCl and reduced P(osm), but the change from baseline was significantly greater in the women with normal ovarian function, indicating that in contrast to the rodent model, other factors in addition to circulating relaxin contribute to gestational renal adaptation to human pregnancy.
Marie C Smith; Alison P Murdoch; Lee A Danielson; Kirk P Conrad; John M Davison
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-05-30
Journal Detail:
Title:  Fertility and sterility     Volume:  86     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-08-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-5     Citation Subset:  IM    
School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, Tyne and Wear, United Kingdom.
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MeSH Terms
Creatinine / blood*
Feedback / physiology
Kidney / metabolism*
Kidney Function Tests*
Metabolic Clearance Rate
Pregnancy / blood*
Relaxin / blood*
Water-Electrolyte Balance / physiology
Grant Support
Reg. No./Substance:
60-27-5/Creatinine; 9002-69-1/Relaxin

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