| Relaxin has a role in establishing a renal response in pregnancy. | |
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MedLine Citation:
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PMID: 16730722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9) had serial measurements of renal function made during the first trimester of pregnancy by using 24-hour creatinine clearance (CrCl) and plasma osmolality (P(osm)). All pregnancies were associated with increasing CrCl and reduced P(osm), but the change from baseline was significantly greater in the women with normal ovarian function, indicating that in contrast to the rodent model, other factors in addition to circulating relaxin contribute to gestational renal adaptation to human pregnancy. |
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Authors:
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Marie C Smith; Alison P Murdoch; Lee A Danielson; Kirk P Conrad; John M Davison |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-05-30 |
Journal Detail:
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Title: Fertility and sterility Volume: 86 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-04 Completed Date: 2006-08-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 253-5 Citation Subset: IM |
Affiliation:
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School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, Tyne and Wear, United Kingdom. m.c.smith@ncl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Creatinine / blood* Feedback / physiology Female Humans Kidney / metabolism* Kidney Function Tests* Metabolic Clearance Rate Pregnancy / blood* Relaxin / blood* Water-Electrolyte Balance / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R0 DK63321/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine; 9002-69-1/Relaxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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