Document Detail

Relaxin Does Not Rescue Coronal Suture Fusion in Craniosynostotic Rabbits.
MedLine Citation:
PMID:  21740159     Owner:  NLM     Status:  Publisher    
Abstract Objectives: Craniosynostosis affects 1 in 2,000-3,000 live births and may result in craniofacial and neural growth disturbances. Histological data have shown that thick collagenous bundles are present in the sutural ligament, which may tether the osteogenic fronts, resulting in premature fusion. The hormone relaxin has been shown to disrupt collagen fiber organization, possibly preventing craniosynostosis by relaxing the sutural ligament and allowing osteogenic fronts to separate normally and stay patent. This study tested this hypothesis in a rabbit model of delayed onset coronal suture synostosis. Methods: 18 New Zealand White rabbits with craniosynostosis were randomly assigned to three groups: Sham control, protein control (BSA), relaxin treatment. After initial diagnosis, sham surgery, BSA, or relaxin were delivered to the fusing coronal suture in a slow release (56 day) collagen vehicle. Longitudinal radiographs and body weights were collected at 10, 25, 42, and 84 days of age and sutures were harvested for histology. Results: Relaxin treated animals had more disorganized intra-suture content than control groups. These specimens also appeared to have relatively wider sutures ectocranially. There were no significant differences in relaxin treated animals for all craniofacial growth measures, or suture separation compared to controls. Conclusions: These data do not support our initial hypothesis that the use of relaxin may rescue sutures destined to undergo premature suture fusion. These findings suggest that collagen fiber arrangement may not be important for suture fusion. This protein therapy would not be clinically useful for craniosynostosis. Key Words: Relaxin, Craniosynostosis, Extracellular Matrix, Collagen Fibers, Cephalometrics.
James J Cray Jr; Annie M Burrows; Lisa Vecchione; Christopher R Kinsella; Joseph E Losee; Amr M Moursi; Michael I Siegel; Gregory M Cooper; Mark P Mooney
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-8
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  -     ISSN:  1545-1569     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a University of Pittsburgh, Surgery/Plastic Surgery.
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