| Relaxation responses of the human proximal stomach to distension during fasting and after food. | |
| | |
MedLine Citation:
|
PMID: 8074216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The responses of the human proximal stomach to distension were studied in 22 healthy volunteers using an intragastric polyethylene bag, inflated progressively in 30-ml steps until the limit of tolerated volume was reached. Three successive inflations were carried out during the fasting state followed by a fourth inflation after ingestion of 250 ml of either a nutrient meal or isosmolar saline. The first inflation showed an initial nonlinear pressure rise (slope of logged pressure vs. volume = 114.6 +/- 10.0 log mmHg/ml x 10(-5)), which was then followed by the development of a plateau phase, in which further distension did not increase intragastric pressure. The slopes of the subsequent fasting inflations were significantly lower than that of the first inflation (P < 0.01) but were similar to each other (slope 83.0 +/- 5.4 and 79.8 +/- 5.7 log mmHg/ml x 10(-5)), indicating that distension-induced gastric relaxation had occurred. After saline ingestion, responses to distension were similar to those during the fasted state. After the nutrient meal ingestion, however, the slope decreased to 60.3 +/- 7.7 log mmHg/ml x 10(-5) (P < 0.01 vs. saline), indicating nutrient-induced gastric relaxation. Our study demonstrates that the pressure-volume characteristics of the proximal stomach are modulated both by distension and by the presence of nutrients in the upper gut, which appear to operate independently. |
| | |
Authors:
|
N K Ahluwalia; D G Thompson; J Barlow; L E Troncon; S Hollis |
Related Documents
:
|
7316286 - Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal m... 2404826 - Postprandial colonic transit and motor activity in chronic constipation. 3337236 - Effects of alterations in bolus viscosity on esophageal peristalsis in humans. 2658576 - Pathophysiology of gastroesophageal reflux. 7994856 - Observations of ventilation during resuscitation in a canine model. 17444886 - Irbesartan reduces common carotid artery intima-media thickness in hypertensive patient... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 267 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1994 Aug |
Date Detail:
|
Created Date: 1994-09-23 Completed Date: 1994-09-23 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G166-72 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Manchester Medical School, Hope Hospital, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Balloon Dilatation* Drinking Eating* Fasting* Female Humans Male Muscle Relaxation* Pressure Sodium Chloride Stomach / physiology* |
| Chemical | |
Reg. No./Substance:
|
7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Integrative immunophysiology in the intestinal mucosa.
Next Document: Role of prostaglandins in angiotensin II-induced gastric vasoconstriction.