| Relaxation Behavior Study of Ultra-Small Superparamagnetic Iron Oxide Nanoparticles at Ultra-Low and Ultra-High Magnetic Fields. | |
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MedLine Citation:
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PMID: 21972868 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) have attracted attention because of their current and potential usefulness as contrast agents for magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR). USPIOs are usually used for their significant capacity to produce predominant proton relaxation effects, which result in signal reduction. However, most previous studies that utilized USPIOs have been focused on the relaxation behavior at commonly used magnetic fields of clinical MRI systems (typically 1 T to 3 T). In this paper, magnetic relaxation processes of proton in water surrounding the USPIOs are studied at ultra-low (≤ 10 mT) and ultra-high magnetic field (14.1 T). USPIOs used in our experiments were synthesized with a core size of 6 nm, and transferred from organic to water by ligand exchange. The proton spin-lattice relaxation time (T1) and spin-spin relaxation time (T2) were investigated at ultra-low (212 µT for T2 and 10 mT for T1) and at 14.1 T with different iron concentrations. At all of the fields, there is a linear relationship between the inverse of relaxation times and the iron concentration. The spin-spin relaxivity (r2) at 14.1 T is much higher than that value of Ultra-low field. At ultra-low field, however, the spin-lattice relaxivity (r1) is higher than the r1 at ultra-high field. The results provide a perspective on potential in vivo and in vitro applications of USPIOs in ultra-low and ultra-high field NMR and MRI. |
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Authors:
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Wei Wang; Hui Dong; Victor Pacheco; Dieter Willbold; Yi Zhang; Andreas Offenhausser; Rudolf Hartmann; Thomas E Weirich; Peixiang Ma; Hans Joachim Krause; Zhongwei Gu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-5 |
Journal Detail:
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Title: The journal of physical chemistry. B Volume: - ISSN: 1520-5207 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101157530 Medline TA: J Phys Chem B Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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