| Relaxant effects of vasoactive intestinal peptide and peptide histidine isoleucine in human and bovine pulmonary arteries. | |
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MedLine Citation:
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PMID: 3567364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the functional effects of vasoactive intestinal peptide (VIP) and the structurally related peptide histidine isoleucine (PHI) in segments of bovine and human intrapulmonary artery. In both species, VIP caused nearly complete relaxation of precontracted vessel segments. The EC50 was 1.3 +/- 0.3 X 10(-9) M (mean +/- SD) in bovine and 3.4 +/- 0.4 X 10(-9) M in human pulmonary artery. The response to VIP was not endothelium-dependent and it was not affected by either adrenergic and cholinergic blockade or by cyclooxygenase inhibition. PHI also relaxed human and bovine vessels but this related peptide was significantly less effective than VIP. We conclude that VIP is a potent inhibitor of bovine and human pulmonary artery, which appears to act directly on vascular smooth muscle. These data support the concept that VIP may be a neurotransmitter which modulates pulmonary artery tone in both man and cow. |
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Authors:
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B Greenberg; K Rhoden; P J Barnes |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood vessels Volume: 24 ISSN: 0303-6847 ISO Abbreviation: Blood Vessels Publication Date: 1987 |
Date Detail:
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Created Date: 1987-06-17 Completed Date: 1987-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0427130 Medline TA: Blood Vessels Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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pharmacology Animals Atropine / pharmacology Cattle Endothelium / drug effects Humans Indomethacin / pharmacology Muscle Relaxation / drug effects Muscle, Smooth, Vascular / drug effects Peptide PHI / pharmacology* Phentolamine / pharmacology Propranolol / pharmacology Pulmonary Artery / drug effects* Vasoactive Intestinal Peptide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Peptide PHI; 37221-79-7/Vasoactive Intestinal Peptide; 50-60-2/Phentolamine; 51-55-8/Atropine; 525-66-6/Propranolol; 53-86-1/Indomethacin; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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