Document Detail

Relaxant effects of vasoactive intestinal peptide and peptide histidine isoleucine in human and bovine pulmonary arteries.
MedLine Citation:
PMID:  3567364     Owner:  NLM     Status:  MEDLINE    
We studied the functional effects of vasoactive intestinal peptide (VIP) and the structurally related peptide histidine isoleucine (PHI) in segments of bovine and human intrapulmonary artery. In both species, VIP caused nearly complete relaxation of precontracted vessel segments. The EC50 was 1.3 +/- 0.3 X 10(-9) M (mean +/- SD) in bovine and 3.4 +/- 0.4 X 10(-9) M in human pulmonary artery. The response to VIP was not endothelium-dependent and it was not affected by either adrenergic and cholinergic blockade or by cyclooxygenase inhibition. PHI also relaxed human and bovine vessels but this related peptide was significantly less effective than VIP. We conclude that VIP is a potent inhibitor of bovine and human pulmonary artery, which appears to act directly on vascular smooth muscle. These data support the concept that VIP may be a neurotransmitter which modulates pulmonary artery tone in both man and cow.
B Greenberg; K Rhoden; P J Barnes
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood vessels     Volume:  24     ISSN:  0303-6847     ISO Abbreviation:  Blood Vessels     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-17     Completed Date:  1987-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0427130     Medline TA:  Blood Vessels     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / pharmacology
Atropine / pharmacology
Endothelium / drug effects
Indomethacin / pharmacology
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects
Peptide PHI / pharmacology*
Phentolamine / pharmacology
Propranolol / pharmacology
Pulmonary Artery / drug effects*
Vasoactive Intestinal Peptide / pharmacology*
Reg. No./Substance:
0/Peptide PHI; 37221-79-7/Vasoactive Intestinal Peptide; 50-60-2/Phentolamine; 51-55-8/Atropine; 525-66-6/Propranolol; 53-86-1/Indomethacin; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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