Document Detail


Relative value of oestrogen receptor assay, lactoferrin content, and glucose-6-phosphate dehydrogenase activity as prognostic indicators in primary breast cancer.
MedLine Citation:
PMID:  3969258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oestrogen receptor content, lactoferrin, hexokinase, and glucose-6-phosphate dehydrogenase levels were measured in cytosol from 25 primary breast cancers and 3 fibroadenomas. Both hexokinase and glucose-6-phosphate dehydrogenase activity were higher in malignant tissue as compared to benign breast lesions. Oestrogen receptor concentration and lactoferrin content failed to predict the development of metastatic disease, while glucose-6-phosphate dehydrogenase activity was significantly higher in cytosol from those tumours which subsequently metastasized compared to those which remained localized.
Authors:
W R Bezwoda; D P Derman; N See; N Mansoor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology     Volume:  42     ISSN:  0030-2414     ISO Abbreviation:  Oncology     Publication Date:  1985  
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenofibroma / analysis,  diagnosis,  pathology
Adult
Aged
Breast Neoplasms / analysis,  diagnosis*,  pathology
Female
Glucosephosphate Dehydrogenase / analysis*
Hexokinase / analysis
Humans
Lactoferrin / analysis
Middle Aged
Neoplasm Metastasis
Prognosis
Receptors, Estrogen / analysis*
Chemical
Reg. No./Substance:
0/Lactoferrin; 0/Receptors, Estrogen; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.7.1.1/Hexokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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