Document Detail

Relative value of glucose and amino acids in preserving exercise capacity in the postoperative period.
MedLine Citation:
PMID:  3976997     Owner:  NLM     Status:  MEDLINE    
The value of crystalline amino acids compared with glucose in maintaining functional muscle mass (maximum exercise capacity) in the perioperative period was studied. Twelve surgical patients received 100 g of glucose (Group 1) for 7 to 10 days perioperatively, and 12 (Group 2) received 90 g of crystalline amino acids for a similar period. Maximum exercise capacity, nitrogen balance, and serum albumin were studied. The use of amino acids instead of glucose spared nitrogen. Net nitrogen loss was 64.7 +/- 6.7 g in Group 1 compared with 34.7 +/- 4 g in Group 2 (p less than or equal to 0.001). Exercise capacity decreased 13.8 +/- 4.5 percent in Group 1 and 13.3 +/- 2.9 percent in group 2. The serum albumin level decreased by 0.30 +/- 0.2 g/100 ml in Group 1 compared with 0.34 +/- 0.15 g/100 ml in Group 2. These differences were not significant. Changes in serum albumin were correlated with changes in exercise capacity (r = 0.7, p less than or equal to 0.002), but neither was significantly correlated with nitrogen loss. We concluded that the use of amino acids instead of glucose during moderate periods of semi-starvation associated with moderate trauma will not influence loss of exercise capacity significantly, although some nitrogen will be spared; patients undergoing moderately severe surgical procedures accompanied by moderate periods of semistarvation will lose approximately 14 percent of their exercise capacity; and loss of exercise capacity is not correlated with loss of nitrogen under these conditions but is loosely correlated with changes in serum albumin levels.
C D Wood; R Shreck; R Tommey; K Towsley; C W Guess; R Werth; M Pollard
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of surgery     Volume:  149     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-25     Completed Date:  1985-04-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-6     Citation Subset:  AIM; IM; S    
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MeSH Terms
Amino Acids / administration & dosage*,  metabolism
Body Weight
Exercise Test
Glucose / administration & dosage*,  metabolism
Middle Aged
Muscles / metabolism*,  physiology
Nitrogen / metabolism
Physical Exertion*
Postoperative Period
Serum Albumin / analysis
Surgical Procedures, Operative*
Reg. No./Substance:
0/Amino Acids; 0/Serum Albumin; 50-99-7/Glucose; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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