Document Detail


Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K.
MedLine Citation:
PMID:  2257487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of calbindin-D28K (CaBP)-positive neurons was investigated by immunohistochemistry in 4 controls, 5 cases of Parkinson's disease and a single case of strionigral degeneration. CaBP-positive neurons were preferentially localized to the mediodorsal portion of the substantia nigra pars compacta (SNC) in the beta layer, while CaBP-negative, melanin-positive neurons were concentrated in the ventrolateral SNC in the alpha layer. In Parkinson's disease and the case of strionigral degeneration, there was a relative sparing of the CaBP-positive neurons compared with CaBP-negative, pigmented neurons. These data imply that CaBP may confer some protection to SNC dopaminergic neurons against the pathological process which is responsible for Parkinson's disease and strionigral degeneration.
Authors:
T Yamada; P L McGeer; K G Baimbridge; E G McGeer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  526     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Calcium-Binding Protein, Vitamin D-Dependent / metabolism*
Cell Count
Cell Survival / physiology
Corpus Striatum / physiology
Dopamine / physiology*
Female
Humans
Immunohistochemistry
Male
Middle Aged
Nerve Degeneration / physiology
Nerve Tissue Proteins / metabolism*
Neural Pathways / physiology
Neurons / metabolism*
Parkinson Disease / metabolism,  physiopathology*
Substantia Nigra / metabolism*
Chemical
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Nerve Tissue Proteins; 0/calbindin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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