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THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES : VII. THE INFLUENCE OF CHANGES IN THE REACTION OF THE BLOOD UPON THE REACTION OF THE TISSUES.
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MedLine Citation:
PMID:  19869227     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The introduction into the blood stream of dilute hydrochloric acid or sodium carbonate in quantities not too great to be compatible with life results in marked alterations in the color of certain of the matrix tissues stainable in vivo with phthalein indicators. Connective tissue in its various forms, and tendon and cartilage all become relatively more acid or alkaline than the normal. The hue of the kidney cortex also changes, as might be expected from its functions. The pancreas and lymph nodes, on the other hand, appear unaffected even when the injection is pushed to the extreme; and the slight to negligible alterations in the hue of the liver may be due to changes in the color of the associated secretion. The matrix tissues just mentioned behave as if unable to maintain a reaction of their own; whereas the elements of the parenchymal organs would seem to make their own conditions even when so much acid or alkali has been injected as will lead to death of the animal. Injections of lactic acid are well tolerated and it is difficult to bring about alterations in the color of the phthalein-stained matrix tissues by means of them. Salt solution, and sugar in large amount cause no changes in color such as would indicate changes in reaction. The results with the various phthalein indicators are in close accord, attesting that the information these give under vital conditions is reliable.
Authors:
P Rous; W W Beattie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  44     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1926 Nov 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-06-23     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  835-54     Citation Subset:  -    
Affiliation:
Laboratories of The Rockefeller Institute for Medical Research.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1926, by The Rockefeller Institute for Medical Research New York
Received Day: 24 Month: 6 Year: 1926
Print publication date: Day: 30 Month: 11 Year: 1926
Volume: 44 Issue: 6
First Page: 835 Last Page: 854
ID: 2131221
PubMed Id: 19869227

THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES : VII. THE INFLUENCE OF CHANGES IN THE REACTION OF THE BLOOD UPON THE REACTION OF THE TISSUES.
Peyton Rous
W. W. Beattie
From the Laboratories of The Rockefeller Institute for Medical Research.


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