| Relative rates of hydrolysis by rat pancreatic lipase of esters of C2-C18 fatty acids with C1-C18 primary n-alcohols. | |
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MedLine Citation:
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PMID: 5802639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rate at which rat pancreatic lipase (glycerol-ester hydrolase, EC 3.1.1.3) hydrolyzes the esters of primary n-alcohols containing from 1 to 18 carbon atoms with fatty acids containing from 2 to 18 carbon atoms was determined. The speed of hydrolysis was influenced, apparently independently, by both the acyl and the alkyl chains. With respect to the fatty acid moiety, the esters of dodecanoic acid were usually split at the most rapid rate. Esters of butyric acid were the next most susceptible. In the case of the alcohol moiety, esters of heptyl alcohol were hydrolyzed most rapidly. On the basis of the pattern of the relative rates of hydrolysis, it is proposed that the influence of the alcohol component is a result of its orienting the ester molecule at the oil/water interface. The fatty acid effect is attributed to enzyme-substrate specificity. |
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Authors:
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F H Mattson; R A Volpenhein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of lipid research Volume: 10 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1969 May |
Date Detail:
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Created Date: 1969-09-30 Completed Date: 1969-09-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 271-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohols* Animals Calcium Chemical Phenomena Chemistry Esters Fatty Acids* Fatty Acids, Nonesterified Freeze Drying Kinetics Lipase* Models, Chemical Pancreatic Juice / enzymology Rats Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Alcohols; 0/Esters; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 7440-70-2/Calcium; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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