Document Detail

Relative protection from cerebral atherosclerosis of young patients with homozygous familial hypercholesterolemia.
MedLine Citation:
PMID:  1799396     Owner:  NLM     Status:  MEDLINE    
It is well known that hypercholesterolemia is correlated with coronary atherosclerosis, but no definite information is available on its association with cerebrovascular atherosclerosis. We studied 10 young patients (age 3-32 years) with homozygous familial hypercholesterolemia (FH), together with 3 normal relatives as healthy controls. Extra- and intracranial Doppler examination, MRI and cerebral blood flow by SPECT and 99mTc-HM-PAO were performed on all. Six out of 10 patients already had signs and symptoms of coronary heart disease, but all patients were free from ischemic brain lesions, as small as detectable at MRI, and had normal cerebral blood flow. Two patients presented significant stenosis of the carotid arteries at Doppler examination. Young patients with homozygous FH have early and clinically evident coronary atherosclerosis, while overt disease in the cerebral district is delayed despite the extremely elevated plasma cholesterol concentration. This was also confirmed by the autopsy of two patients, who died after the study and whose cerebral arteries were totally free from atherosclerotic lesions. The age, at which flow-reducing atherosclerotic lesions develop in hypercholesterolemic patients, differs with regard to the arterial district involved.
A Postiglione; A Nappi; A Brunetti; A Soricelli; P Rubba; A Gnasso; M Cammisa; V Frusciante; C Cortese; M Salvatore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  90     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-04-16     Completed Date:  1992-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Institute of Internal Medicine and Metabolic Diseases, University of Naples, Italy.
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MeSH Terms
Cerebral Arteries / pathology
Child, Preschool
Coronary Vessels / pathology
Hyperlipoproteinemia Type II / complications*,  diagnosis,  genetics,  pathology
Intracranial Arteriosclerosis / complications*

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