| Relative peripheral refractive error and the risk of onset and progression of myopia in children. | |
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MedLine Citation:
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PMID: 20739476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate whether relative peripheral hyperopia is a risk factor for either the onset of myopia in children or the rate of myopic progression. METHODS: The risk of myopia onset was assessed in 2043 nonmyopic third-grade children (mean age ± SD = 8.8 ± 0.52 years) participating in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study between 1995 and 2007, 324 of whom became myopic by the eighth grade. Progression analyses used data from 774 myopic children in grades 1 to 8. Foveal and relative peripheral refractive error 30° in the nasal visual field was measured annually by using cycloplegic autorefraction. Axial length was measured by A-scan ultrasonography. RESULTS: The association between more hyperopic relative peripheral refractive error in the third grade and the risk of the onset of myopia by the eighth grade varied by ethnic group (Asian children odds ratio [OR] = 1.56, 95% confidence interval [CI] = 1.06-2.30; African-American children OR = 0.75, 95% CI = 0.58-0.96; Hispanics, Native Americans, and whites showed no significant association). Myopia progression was greater per diopter of more hyperopic relative peripheral refractive error, but only by a small amount (-0.024 D per year; P = 0.02). Axial elongation was unrelated to the average relative peripheral refractive error (P = 0.77), regardless of ethnicity. CONCLUSIONS: Relative peripheral hyperopia appears to exert little consistent influence on the risk of the onset of myopic refractive error, on the rate of myopia progression, or on axial elongation. |
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Authors:
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Donald O Mutti; Loraine T Sinnott; G Lynn Mitchell; Lisa A Jones-Jordan; Melvin L Moeschberger; Susan A Cotter; Robert N Kleinstein; Ruth E Manny; J Daniel Twelker; Karla Zadnik; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-05 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-06 Completed Date: 2011-02-07 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 199-205 Citation Subset: IM |
Affiliation:
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The Ohio State University College of Optometry, Columbus, OH, USA. mutti.2@osu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Axial Length, Eye Child Disease Progression Ethnic Groups Female Follow-Up Studies Humans Hyperopia / complications*, ethnology Male Myopia / etiology*, physiopathology* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R24-EY014792/EY/NEI NIH HHS; U10-EY08893/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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