Document Detail


Relative motion of lung and chest wall promotes uniform pleural space thickness.
MedLine Citation:
PMID:  12126924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pleural space is modeled in two dimensions as a thin layer of fluid separating a deformable membrane and a rigid surface containing a bump. We computed the steady-state membrane configuration and fluid pressure distribution during relative sliding of the two surfaces. For physiologically relevant values of membrane tension, shear flow-induced pressures near the bump and far-field pressure gradients are similar to those measured in vivo within the pleural space (e.g. Lai-Fook et al.) [J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 56 (1984) 1633-1639]. Deformation of the membrane over the bump suggests that the pressure field generated by the sliding motion promotes an even layer of fluid in the pleural space, preventing asperities from touching. Results also suggest a possible mechanism for pleural fluid redistribution during breathing, whereby irreversible fluid motion is associated with the deformability of the membrane.
Authors:
Jean Lai; Andrew Gouldstone; James P Butler; William J Federspiel; Stephen H Loring
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  131     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2002-10-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  233-43     Citation Subset:  IM    
Affiliation:
Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Fluids / physiology
Lung / physiology*
Models, Biological*
Pleura / physiology*
Stress, Mechanical
Thorax / physiology*
Grant Support
ID/Acronym/Agency:
HL07118/HL/NHLBI NIH HHS; HL33009/HL/NHLBI NIH HHS; HL63737/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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