| Relative lung and systemic bioavailability of sodium cromoglycate inhaled products using urinary drug excretion post inhalation. | |
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MedLine Citation:
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PMID: 12015790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relative lung and systemic bioavailability of sodium cromoglycate following inhalation by different methods have been determined using a urinary excretion pharmacokinetic method. On three separate randomised study days, 7 days apart, subjects inhaled (i) 4x5 mg from an Intal metered dose inhaler (MDI), (ii) 4x5 mg from an MDI attached to a large volume spacer (MDI+SP) and (iii) 20 mg from an Intal Spinhaler (DPI). Urine samples were provided at 0, 0.5, 1, 2, 5 and 24 h post dose. The mean (S.D.) amount of sodium cromoglycate excreted in the urine during the first 30 min post inhalation was 38.1 (27.5), 222.3 (120.3) and 133.1 (92.2) microg following MDI, MDI+SP and DPI, respectively. The mean ratio (90% confidence interval) of these amounts excreted in the urine over the first 30 min for MDI+SP vs. MDI, DPI vs. MDI and MDI+SP vs. DPI was 801.0 (358.0, 1244; p<0.002)%, 457.0 (244.0, 670.0; p<0.02)% and 262.4 (110.2, 414.5)%, respectively. Similarly for the 24 h cumulative amount of sodium cromoglycate excreted over the 24 h post inhalation the ratios were 375.4 (232.9, 517.9; p<0.005)%, 287.5 (183.4, 391.6; p<0.02)% and 211.4 (88.3, 334.5)%, respectively. The results highlight better lung deposition of sodium cromoglycate from a metered dose inhaler attached to a large volume spacer. |
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Authors:
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Osama Aswania; Henry Chrystyn |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 23 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-23 Completed Date: 2002-07-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: England |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: IM |
Copyright Information:
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Copyright 2002 John Wiley & Sons, Ltd. |
Affiliation:
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School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Anti-Asthmatic Agents / administration & dosage, pharmacokinetics*, urine Biological Availability Cromolyn Sodium / administration & dosage, pharmacokinetics*, urine Dose-Response Relationship, Drug Female Humans Lung / metabolism* Male Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents; 15826-37-6/Cromolyn Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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