Document Detail


Relative influences of adjunctive topiramate and adjunctive lamotrigine on scanning and the effective field of view.
MedLine Citation:
PMID:  18155445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A subsample of 67 adult patients with partial seizures participating in a randomized, double-blind study comparing the cognitive effects of adjunctive lamotrigine (LTG) and adjunctive topiramate (TPM) was administered Performance On-Line (POL) in addition to a battery of neuropsychological tests at baseline, week 8 and week 16 of treatment. The POL is a self-administered computer task that measures scanning, divided-attention, and the effective field of view. Although the POL does not measure driving performance, POL scores are correlated with driving performance. The results show that adjunctive TPM, but not adjunctive LTG, negatively impacted cognition. Both simple target identification and divided-attention performance on POL were compromised in the TPM group but not in the LTG group. The relative POL impairment associated with chronic TPM treatment was similar to that observed with the acute effects of alcohol with a breath level of .045% or a low dose of alprazolam (0.5mg). Thus, driving-related visual and cognitive skills were compromised by adjunctive TPM treatment. Therapeutic doses of adjunctive TPM pose a potential risk of impaired scanning and divided-attention skills.
Authors:
Kenneth C Mills; Joseph F Drazkowski; Anne E Hammer; Paul T Caldwell; Robert P Kustra; David E Blum
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-12-21
Journal Detail:
Title:  Epilepsy research     Volume:  78     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-04-23     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  140-6     Citation Subset:  IM    
Affiliation:
Profile Associates, Chapel Hill, NC, United States. profiler@intrex.net
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anticonvulsants / adverse effects*,  therapeutic use
Cognition / drug effects
Data Interpretation, Statistical
Double-Blind Method
Drug Therapy, Combination
Epilepsy / complications*,  drug therapy
Female
Fructose / adverse effects,  analogs & derivatives*,  therapeutic use
Humans
Male
Middle Aged
Neuropsychological Tests
Seizures / drug therapy,  epidemiology
Triazines / adverse effects*,  therapeutic use
Vision Disorders / chemically induced*,  psychology
Visual Fields / drug effects*
Visual Perception / drug effects
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 0H73WJJ391/topiramate; 30237-26-4/Fructose; U3H27498KS/lamotrigine
Comments/Corrections
Erratum In:
Epilepsy Res. 2009 Sep;86(1):99

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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