Document Detail

Relative importance of genetic effects in rheumatoid arthritis: historical cohort study of Danish nationwide twin population.
MedLine Citation:
PMID:  11823356     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the relative importance of environmental and genetic effects in the development of rheumatoid arthritis.
DESIGN: Historical cohort study with record linkage between a twin registry and the Danish discharge registry as well as the Danish national registry of deaths used to estimate completeness.
SETTING: Two population based nationwide twin birth cohorts.
PARTICIPANTS: 37 338 twins were sent a questionnaire about rheumatic diseases. Self reported rheumatoid arthritis was verified by clinical examination and from medical records.
MAIN OUTCOME MEASURES: The probandwise concordance rate of rheumatoid arthritis in monozygotic and dizygotic twins.
RESULTS: The response rate was 84.7%. Rheumatoid arthritis was verified in 13 monozygotic and 36 dizygotic twins. There were no concordant monozygotic twin pairs and two concordant dizygotic twin pairs. Based on capture-recapture methods the probability of ascertainment was 78.3%. The probandwise concordance rate was 0 (95% confidence interval 0 to 24.7) in monozygotic twins and 8.8 (1.9 to 23.7) in dizygotic twins.
CONCLUSION: Genes are of minor importance in the development of rheumatoid arthritis.
Anders J Svendsen; Niels V Holm; Kirsten Kyvik; Per Hyltoft Petersen; Peter Junker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  324     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-01     Completed Date:  2002-04-23     Revised Date:  2012-03-06    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  264-6     Citation Subset:  AIM; IM    
Department of Rheumatology, Odense University Hospital, 5000 Odense C, Denmark.
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MeSH Terms
Arthritis, Rheumatoid / genetics*
Cohort Studies
Diseases in Twins / genetics*
Genetic Predisposition to Disease
Twins, Dizygotic
Twins, Monozygotic
Comment In:
BMJ. 2002 May 4;324(7345):1100-1   [PMID:  11991930 ]
BMJ. 2002 Feb 2;324(7332):264   [PMID:  11936132 ]

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