Document Detail


Relative importance of corticosterone and thyroxine in the postnatal development of sucrase and maltase in rat small intestine.
MedLine Citation:
PMID:  7049675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both corticosterone and T4 have been previously implicated as causal factors in the ontogenic increases in jejunal sucrase and maltase activities during the third week of life in the rat. Furthermore, it is known that the administration of exogenous T4 during the developmental period causes significant increases in serum corticosterone concentrations. To determine whether the effects of T4 on sucrase and maltase are secondary to the corticosterone rise, we examined the effect of T4 administration in adrenalectomized (adX) pups. Serum corticosterone was measured in all operated animals. Some of the adX pups had substantial concentrations of circulating corticosterone. In adX pups with serum corticosterone levels below 0.1 microgram/dl, there was no effect of T4 on either maltase or sucrase activity. We also studied the effect of propylthiouracil-induced hypothyroidism on sucrase and maltase. At 21 days of age, both enzyme activities were significantly reduced in hypothyroid pups. Injections of either T4 or cortisone acetate were equally effective in restoring activities to normal. For sucrase, there was no further increase in activity when both hormones were administered. For maltase, the combined treatment gave activities that were significantly higher than those with either hormone alone. We conclude that for both sucrase and maltase, the effects of changes in thyroid status are primarily due to the accompanying changes in serum corticosterone. The normal rate of development of both enzymes appears to be principally under glucocorticoid control, although for maltase, T4 may have a facilitory action.
Authors:
G R Martin; S J Henning
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  111     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  912-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy
Animals
Corticosterone / blood*
Cortisone / pharmacology
Female
Glucosidases / metabolism*
Hypothyroidism / enzymology
Intestine, Small / enzymology*,  growth & development
Pregnancy
Rats
Rats, Inbred Strains
Sucrase / metabolism*
Thyroxine / pharmacology*
alpha-Glucosidases / metabolism*
Grant Support
ID/Acronym/Agency:
R01-HD-14094/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
50-22-6/Corticosterone; 53-06-5/Cortisone; 7488-70-2/Thyroxine; EC 3.2.1.-/Glucosidases; EC 3.2.1.20/alpha-Glucosidases; EC 3.2.1.48/Sucrase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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