Document Detail


Relative efficiencies of three ultraviolet radiation wavelengths for cell killing and transformation in mouse cells in vitro.
MedLine Citation:
PMID:  6604708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C3H 10 T 1/2 clone 8 mouse cells were irradiated in vitro with three U.V. wavelengths 280, 254, and 230 nm. Two effects were investigated, survival and malignant transformation, and the relative efficiencies were determined for the three radiations. For transformation, these efficiencies were: 280nm:3.9; 254nm:5.1; 230nm:2.3 (transformations produced by 5 Jm-2 of U.V. for 1000 surviving cells). For cell killing the efficiencies were, in relative units, 34, 100, and 50 respectively. These efficiencies are in agreement with the hypothesis that the main chromophore for both effects is the nucleic acid, and not the protein moiety of the genome. This conclusion agrees with that previously reached by other investigators, but our present results obtained with the short wave-length 230 nm provide an especially strong new argument.
Authors:
D Papadopoulo; B Muel; R Latarjet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of radiation biology and related studies in physics, chemistry, and medicine     Volume:  44     ISSN:  0020-7616     ISO Abbreviation:  Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374725     Medline TA:  Int J Radiat Biol Relat Stud Phys Chem Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Survival / radiation effects*
Cell Transformation, Neoplastic / radiation effects*
Dose-Response Relationship, Radiation
Mice
Relative Biological Effectiveness
Ultraviolet Rays*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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