Document Detail


Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults.
MedLine Citation:
PMID:  22552038     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The relative potency of 25-hydroxyvitamin D(3) to vitamin D(3) needs to be better defined so that food-composition tables can better reflect the true vitamin D nutritive value of certain foods. OBJECTIVE: We performed a randomized, controlled intervention study in apparently healthy, free-living adults to investigate whether the intake of 25-hydroxyvitamin D(3) is 5 times more potent in raising serum 25-hydroxyvitamin D [25(OH)D] during winter compared with an equivalent amount of vitamin D(3). DESIGN: A randomized, placebo-controlled, double-blind intervention study was conducted in adults aged ≥50 y (n = 56) who consumed a placebo, 20 μg vitamin D(3), or 7 or 20 μg 25-hydroxyvitamin D(3) daily throughout 10 wk of winter. Serum 25(OH)D was measured by using an enzyme-linked immunoassay, and serum albumin-corrected calcium (S-Ca) was assessed colorimetrically at the baseline, midpoint, and endpoint of the study. RESULTS: The mean (±SD) increases (per microgram of vitamin D compound) in serum 25(OH)D concentrations over baseline after 10 wk of supplementation were 0.96 ± 0.62, 4.02 ± 1.27, and 4.77 ± 1.04 nmol ⋅ L(-1) ⋅ μg intake(-1) for the 20-μg vitamin D(3)/d and 7- and 20-μg 25-hydroxyvitamin D(3)/d groups, respectively. A comparison of the 7- and 20-μg 25-hydroxyvitamin D(3)/d groups with the 20-μg vitamin D(3)/d group yielded conversion factors of 4.2 and 5, respectively. There was no effect of treatment on S-Ca concentrations and no incidence of hypercalcemia (S-Ca >2.6 nmol/L). CONCLUSIONS: Each microgram of orally consumed 25-hydroxyvitamin D(3) was about 5 times more effective in raising serum 25(OH)D in older adults in winter than an equivalent amount of vitamin D(3). This conversion factor could be used in food-compositional tables for relevant foods. This study was registered at clinicaltrials.gov as NCT01398202.
Authors:
Kevin D Cashman; Kelly M Seamans; Alice J Lucey; Elisabeth Stöcklin; Peter Weber; Mairead Kiely; Tom R Hill
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-2
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  -     ISSN:  1938-3207     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Food and Nutritional Sciences and the Department of Medicine, University College Cork, Cork, Ireland, and DSM Nutritional Products Ltd, Kaiseraugst, Switzerland.
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