| Relative contributions of genes, environment, and interactions to blood lipid concentrations in a general adult population. | |
| | |
MedLine Citation:
|
PMID: 15800263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The authors evaluated the contributions of nine genetic (G) variants (selected from 275 single nucleotide polymorphisms in 11 reverse cholesterol transport pathway genes), five environmental (E) factors (selected from 10), and G x G, E x E, and G x E interactions in explaining population variance of blood lipid concentrations. Total cholesterol, triglycerides, and high density lipoprotein (HDL) cholesterol were measured, and low density lipoprotein (LDL) cholesterol and HDL cholesterol/LDL cholesterol ratio were calculated in a population-based random sample of 1,543 men and women in Geneva, Switzerland, aged 35-74 years in 1999-2001. Explained variances (R2) for HDL cholesterol/LDL cholesterol ratio, HDL cholesterol, and LDL cholesterol, respectively, were 34%, 33%, and 19%, decomposed into main effects of G (6%, 4%, and 5%) and E (25%, 28%, and 11%), with just 3%, 2%, and 3% due to G x G, E x E, and G x E interactions, respectively. Risk factor clustering was only moderate: 70% of study subjects had < or =3 variants, 75% had < or =2 environmental exposures, and 69% had < or =5 of both types of factors. Multiple genes with weak associations, together with more dominating environmental factors, are involved in determining blood lipid concentrations. Interactions added little explained variance. Increasing trends in hypercholesterolemia are attributable to environmental changes affecting populations as a whole. Reducing obesity and smoking and moderating alcohol intake in entire populations should remain the primary strategies for lipid control. |
| | |
Authors:
|
Michael C Costanza; Eftihia Cayanis; Barbara M Ross; Maria Sol Flaherty; Gabriela B Alvin; Kamna Das; Alfredo Morabia |
Related Documents
:
|
6137813 - Thiazides, beta blockers and lipoproteins. 21490773 - Methotrexate in atherogenesis and cholesterol metabolism. 16499643 - Intranasal steroid reduces exhaled bronchial cysteinyl leukotrienes in allergic patients. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of epidemiology Volume: 161 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2005 Apr |
Date Detail:
|
Created Date: 2005-03-31 Completed Date: 2005-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
|
Languages: eng Pagination: 714-24 Citation Subset: IM |
Affiliation:
|
Division of Clinical Epidemiology, Geneva University Hospitals, Geneva, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Alcohol Drinking Body Mass Index Cholesterol, HDL / blood, genetics Cholesterol, LDL / blood, genetics Dietary Fats / administration & dosage Educational Status Environment* Female Humans Life Style Lipids / blood*, genetics* Male Middle Aged Polymorphism, Single Nucleotide Questionnaires Risk Factors Smoking / blood Switzerland Triglycerides / blood, genetics |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Lipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polygenic effects and cigarette smoking account for a portion of the familial aggregation of nuclear...
Next Document: The probability of giving birth among women who were born preterm or with impaired fetal growth: a S...