Document Detail


Relative contributions of aqueous and dietary uptake of hydrophobic chemicals to the body burden in juvenile rainbow trout.
MedLine Citation:
PMID:  10948288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed the relative contributions of aqueous versus dietary uptake of three hydrophobic chemicals, 1,2, 4-trichlorobenzene (1,2,4-TCB), 1,2,3,4,5-pentachlorobenzene (PeCB), and 2,2',4,4',6,6'-hexachlorobiphenyl (HCBP). Juvenile rainbow trout (Oncorhynchus mykiss) were exposed separately to chemically spiked water and food for 4 days and 12 days, respectively. Chemical concentrations were measured in the food, water, and tissues, and this allowed calculation of uptake rate constants (k(1) from water exposure, k(d) from food exposure). The k(1) values for the three test chemicals were approximately five orders of magnitude greater than the k(d) values. Using these measured uptake rate constants, a simulation model was used to predict the relative aqueous versus dietary uptake when fish were exposed simultaneously to water and food contaminated with these hydrophobic chemicals. The model predicted for all three test chemicals that the two uptake routes would contribute equally to the chemical body burden in fish whenever the food:water chemical concentration ratio was near 10(5). However, using food:water chemical concentration ratios that might be expected in nature, the model predicted that gill uptake could account for over 98% of fish body burden for both 1,2,4-TCB and PeCB uptake (log K(ow) values of 3.98 and 5.03, respectively). For HCBP (log K(ow) of 7.55), the model predicted that the dietary uptake could contribute over 85% of the body burden. Thus, depending on the actual food:water chemical concentration ratio, aqueous uptake via the gills can predominate even when the chemicals have a log K(ow) value greater than 5.0. In addition, we confirmed that dietary uptake of hydrophobic xenobiotics increases with increasing log K(ow).
Authors:
P Qiao; F A Gobas; A P Farrell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  39     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-19     Completed Date:  2000-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-77     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Body Burden
Chlorobenzenes / chemistry*,  metabolism,  toxicity
Diet
Models, Theoretical
Polychlorinated Biphenyls / chemistry*,  metabolism,  toxicity
Trout / metabolism*
Water Pollutants, Chemical / metabolism*
Chemical
Reg. No./Substance:
0/Chlorobenzenes; 0/Polychlorinated Biphenyls; 0/Water Pollutants, Chemical; 120-82-1/1,2,4-trichlorobenzene; 33979-03-2/2,4,6,2',4',6'-hexachlorobiphenyl; 608-93-5/pentachlorobenzene

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