Document Detail

Relative chromium response as an indicator of chromium status.
MedLine Citation:
PMID:  665555     Owner:  NLM     Status:  MEDLINE    
Twenty-seven women ages 40 to 75 were divided into normal (n = 15) and hyperglycemic (n = 12) groups on the basis of 3-hr glucose tolerance tests. Each subject received 5 g of brewer's yeast extract containing 4 microgram of chromium daily for 3 months. Glucose, insulin, and chromium levels were analyzed by oxidase, radioimmunoassay, and radiochemical neutron activation analysis methods, respectively. The fasting and 1-hr serum chromium levels (ng/ml) changed from 1.67 and 1.43 to 1.46 and 1.86 in the normal group, and from 1.89 and 1.03 to 0.94 and 1.03 in the hyperglycemic group. Considerable changes occurred in the relative chromium response (RCR) at the 1-hr point. RCR is defined as (1-hr serum chromium level/fasting serum chromium level) X 100. Among the normal subjects, 73% showed an improved RCR after the supplementation: mean RCR was 107% before and 140% after. Among the hyperglycemic subjects, 75% showed an improved RCR: mean RCR was 81% before and 149% after the supplementation. The increased RCR was associated with decreased serum insulin and glucose levels. This is interpreted as reflecting an improved chromium status for the majority of individuals in both groups after the supplementation. The observations suggest that 1) in response to a glucose load, serum chromium levels drop in subjects with presumably inadequate chromium storage; 2) a low value of relative chromium response at the 1-hr point indicates a suboptimal chromium nutritional status.
V J Liu; J S Morris
Related Documents :
10860185 - Background and recruitment data for the u.s. diabetes prevention program.
7026595 - Glucose intolerance and insulin resistance in aplastic anemia treated with oxymetholone.
10942475 - Oral contraceptive use and glucose metabolism in a national sample of women in the unit...
6995475 - Correlation of hyperprolactinemia with altered plasma insulin and glucagon: similarity ...
21910085 - Glycosphingolipids and insulin resistance.
10343415 - Serum and urine selenium concentrations as indicators of body status in patients with d...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  31     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-08-28     Completed Date:  1978-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  972-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Glucose / metabolism*
Chromium / blood,  diagnostic use,  metabolism*
Glucose Tolerance Test
Hyperglycemia / metabolism*
Insulin / blood
Middle Aged
Nutritional Requirements
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Digestion of certain fractions of dietary fiber in humans.
Next Document:  Protein and energy utilization in men given a rural Guatemalan diet and egg formulas with and withou...