Document Detail

Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries.
MedLine Citation:
PMID:  23022765     Owner:  NLM     Status:  MEDLINE    
The relative biological effectiveness (RBE) of passive scattered (PS) and pencil beam scanned (PBS) proton beam delivery techniques for uniform beam configurations was determined by clonogenic survival. The radiobiological impact of modulated beam configurations on cell survival occurring in- or out-of-field for both delivery techniques was determined with intercellular communication intact or physically inhibited. Cell survival responses were compared to those observed using a 6 MV photon beam produced with a linear accelerator. DU-145 cells showed no significant difference in survival response to proton beams delivered by PS and PBS or 6 MV photons taking into account a RBE of 1.1 for protons at the centre of the spread out Bragg peak. Significant out-of-field effects similar to those observed for 6 MV photons were observed for both PS and PBS proton deliveries with cell survival decreasing to 50-60% survival for scattered doses of 0.05 and 0.03 Gy for passive scattered and pencil beam scanned beams respectively. The observed out-of-field responses were shown to be dependent on intercellular communication between the in- and out-of-field cell populations. These data demonstrate, for the first time, a similar RBE between passive and actively scanned proton beams and confirm that out-of-field effects may be important determinants of cell survival following exposure to modulated photon and proton fields.
Karl T Butterworth; Conor K McGarry; Ben Clasie; Alejandro Carabe-Fernandez; Jan Schuemann; Nicolas Depauw; Shikui Tang; Stephen J McMahon; Giuseppe Schettino; Joe M O'Sullivan; Hsaio-Ming Lu; Hanne Kooy; Harald Paganetti; Alan R Hounsell; Kathryn D Held; Kevin M Prise
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-01
Journal Detail:
Title:  Physics in medicine and biology     Volume:  57     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  2013-02-21     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6671-80     Citation Subset:  IM    
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MeSH Terms
Cell Communication / radiation effects
Cell Line, Tumor
Cell Survival / radiation effects
Proton Therapy*
Relative Biological Effectiveness
Scattering, Radiation*
Grant Support
C06 CA059267/CA/NCI NIH HHS; C1513/A7047//Cancer Research UK; C212/A11342//Cancer Research UK; G1100014//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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