| Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. | |
| | |
MedLine Citation:
|
PMID: 23022765 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The relative biological effectiveness (RBE) of passive scattered (PS) and pencil beam scanned (PBS) proton beam delivery techniques for uniform beam configurations was determined by clonogenic survival. The radiobiological impact of modulated beam configurations on cell survival occurring in- or out-of-field for both delivery techniques was determined with intercellular communication intact or physically inhibited. Cell survival responses were compared to those observed using a 6 MV photon beam produced with a linear accelerator. DU-145 cells showed no significant difference in survival response to proton beams delivered by PS and PBS or 6 MV photons taking into account a RBE of 1.1 for protons at the centre of the spread out Bragg peak. Significant out-of-field effects similar to those observed for 6 MV photons were observed for both PS and PBS proton deliveries with cell survival decreasing to 50-60% survival for scattered doses of 0.05 and 0.03 Gy for passive scattered and pencil beam scanned beams respectively. The observed out-of-field responses were shown to be dependent on intercellular communication between the in- and out-of-field cell populations. These data demonstrate, for the first time, a similar RBE between passive and actively scanned proton beams and confirm that out-of-field effects may be important determinants of cell survival following exposure to modulated photon and proton fields. |
| | |
Authors:
|
Karl T Butterworth; Conor K McGarry; Ben Clasie; Alejandro Carabe-Fernandez; Jan Schuemann; Nicolas Depauw; Shikui Tang; Stephen J McMahon; Giuseppe Schettino; Joe M O'Sullivan; Hsaio-Ming Lu; Hanne Kooy; Harald Paganetti; Alan R Hounsell; Kathryn D Held; Kevin M Prise |
Related Documents
:
|
14611465 - Collective atomic motion in an optical lattice formed inside a high finesse cavity. 19113605 - Topological degeneracy and vortex manipulation in kitaev's honeycomb model. 15698205 - Variational description of mott insulators. 10991375 - Observation of harmonic generation and nonlinear coupling in the collective dynamics of... 21288525 - Design and validation of surface-marker clusters for the quantification of joint rotati... 21489425 - Reliability and validity of 4d rasterstereography under dynamic conditions. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-01 |
Journal Detail:
|
Title: Physics in medicine and biology Volume: 57 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: - |
Other Details:
|
Languages: ENG Pagination: 6671-6680 Citation Subset: - |
Affiliation:
|
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Of blood cells and the nervous system: Hematopoiesis in the Drosophila larva.
Next Document: Complete trunk severance of a motorcyclist by a traffic sign post at a comparably low collision spee...