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Relative biological effectiveness (RBE) of fast neutrons in trabecular bone architecture in mice.
MedLine Citation:
PMID:  21823819     Owner:  NLM     Status:  Publisher    
ABSTRACT Purpose: This study compares the effects of high linear energy transfer (LET) fast neutrons on the induction of bone loss in mouse tibia with those of low LET (60)Co γ-rays. Materials and Methods: The mice that had received 0-6 Gy of γ-rays or 0-2.4 Gy of neutrons were examined 12 weeks after irradiation. Tibiae were analyzed using microcomputed tomography. Serum markers, biomechanical property, and osteoclast surface were measured. Results: Micro-computed tomography revealed that proximal tibial metaphysis from irradiation group had lower trabecular bone compared to the sham group. Bone loss was markedly enhanced by irradiation. Mean neutron relative biological effectiveness values (Ref. gamma) of 2.05 and 2.33 were estimated for irradiation of trabecular bone volume fraction and of bone mineral density, respectively. There was a substantial reduction in osteoclast surface of tibial metaphyses in irradiated mice with high dose of neutrons. Conclusions: There was a significant relationship between the loss of bone archtecture and the radiation dose. Neutron irradiation had a more marked effect on osteoclast activity than gamma irradiation.
Miyoung Yang; Hae-June Lee; Jin-Hee Lee; Changjong Moon; Jong-Choon Kim; Uhee Jung; Sung-Kee Jo; Jong-Sik Jang; Chang-Mo Kang; Sung-Ho Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-8
Journal Detail:
Title:  International journal of radiation biology     Volume:  -     ISSN:  1362-3095     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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