Document Detail

Relative afferent pupillary defect in glaucoma: a pupillometric study.
MedLine Citation:
PMID:  17573859     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study the presence of relative afferent pupillary defect (RAPD) in patients with glaucoma with the help of a custom-built pupillometer. METHODS: Sixty-five participants were recruited (32 with open-angle glaucoma and 33 healthy subjects). All underwent standard clinical examination including perimetry and optic disc photography. Pupillary light reflexes were examined with a custom-built pupillometer. Three video sequences were recorded for each subject. Alternating light stimulation with a duration of 0.5 seconds was used, followed by a 1 second pause. Mean values of pupil area ratio (PAR), pupil contraction velocity ratio (PCVR), and pupil dilation velocity ratio (PDVR) were calculated. Receiver operating characteristic (ROC) curves were constructed for each of the three parameters. Intra-individual variability was estimated. RESULTS: PAR and PDVR differed significantly between the group with glaucoma and the control group (P < 0.0001). PAR was more sensitive for glaucoma detection than the other pupillometric parameters (PCVR and PDVR). The area under the receiver operating characteristic curve was largest for PAR. At a fixed specificity of 90%, sensitivity for PAR was 86.7%. CONCLUSION: Measuring RAPD with infrared computerized pupillometry can detect optic neuropathy in glaucoma with high sensitivity and specificity. The method is fast and objective. Pupil area amplitude measurements were superior to pupil velocity measurements for the detection of RAPD in glaucoma.
Lada Kalaboukhova; Vanja Fridhammar; Bertil Lindblom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-15
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  85     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-09-25     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  519-25     Citation Subset:  IM    
Institute of Neuroscience and Physiology/Ophthalmology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
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MeSH Terms
Diagnostic Techniques, Ophthalmological
Glaucoma, Open-Angle / complications*,  diagnosis
Middle Aged
Optic Disk / pathology
Optic Nerve Diseases / complications*,  diagnosis
Pupil Disorders / complications*,  diagnosis
Reflex, Pupillary
Sensitivity and Specificity
Visual Fields

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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