Document Detail

Relative adrenal insufficiency in the preterm and term infant.
MedLine Citation:
PMID:  19399009     Owner:  NLM     Status:  MEDLINE    
Cortisol release in the face of illness or stress is vital for survival. Relative adrenal insufficiency occurs when a patient's cortisol response is inadequate for the degree of illness or stress. Numerous studies have documented the existence of relative adrenal insufficiency in critically ill adults, and its association with increased morbidity and mortality. There is increasing evidence that relative adrenal insufficiency may be an etiology for hemodynamic instability and hypotension in the critically ill newborn, but compared with the adult population, there is still a paucity of data in this population. Randomized controlled trials are needed to evaluate the efficacy and safety of glucocorticoids for the treatment of cardiovascular insufficiency due to relative adrenal insufficiency in ill preterm and term newborn infants.
E F Fernandez; K L Watterberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  29 Suppl 2     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-08-04     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S44-9     Citation Subset:  IM    
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MeSH Terms
Adrenal Insufficiency / blood,  complications,  congenital*,  diagnosis,  drug therapy
Adrenocorticotropic Hormone / blood,  therapeutic use
Anti-Inflammatory Agents / adverse effects,  therapeutic use
Blood Pressure / drug effects,  physiology
Dose-Response Relationship, Drug
Gestational Age
Hemodynamics / drug effects,  physiology
Hydrocortisone / adverse effects,  blood,  therapeutic use
Hypothalamo-Hypophyseal System / drug effects,  physiopathology
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / blood,  diagnosis*,  drug therapy
Intensive Care, Neonatal
Pituitary-Adrenal System / drug effects,  physiopathology
Respiration, Artificial
Reg. No./Substance:
0/Anti-Inflammatory Agents; 9002-60-2/Adrenocorticotropic Hormone; WI4X0X7BPJ/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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