Document Detail


Relative acute neurotoxicity of solvents: isoeffective air concentrations of 48 compounds evaluated in rats and mice.
MedLine Citation:
PMID:  8055839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effect-air concentration regressions of 48 common solvents (aromatic, aliphatic, and chlorinated hydrocarbons, alcohols, ketones, acetates) were determined for 4-hr inhalation exposures in male rats and for 2-hr exposures in female mice. Inhibition of propagation and maintenance of the electrically evoked seizure discharge was used as a criterion of the acute neurotropic effect. The isoeffective concentrations in air were estimated by interpolation on the level of one-third of the maximum effect (ECC). ECC estimates ranged from 90 to 24,000 ppm and were several times lower than concentrations evoking behavioral inhibition and by one to two orders lower than concentrations inducing narcosis. Correlations between corresponding values in both species were high (r > 0.9), indicating a relative independence of the estimates from experimental conditions. The relative potency estimates had only negligible correlation with octanol:water distribution coefficients or other physicochemical predictors for the whole sample of solvents, but moderate to high correlation (r = 0.5 to 0.9) in homogenous groups of nonpolar solvents, permitting cautious predictions. When applied to known effective concentrations of some solvents on human performance and subjective state, the comparative potency procedure suggests that ceiling and STEL values of some solvents may not reliably protect workers from acute nervous depression.
Authors:
E Frantík; M Hornychová; M Horváth
Related Documents :
10781869 - Estimation of human exposure to styrene and ethylbenzene.
1984979 - Cough in hot pepper workers.
20136739 - Bisphenol a: how the most relevant exposure sources contribute to total consumer exposure.
20738819 - The impact of consumer phase models in microbial risk analysis.
20628929 - Dietary exposure to metals and other elements in the 2006 uk total diet study and some ...
18996069 - Food cue exposure and body image satisfaction: the moderating role of bmi and dietary r...
16646479 - Gaseous hexane biodegradation by fusarium solani in two liquid phase packed-bed and sti...
18040989 - Brominated flame retardants in us food.
10092419 - Motor function in aging great lakes fisheaters.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  66     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-09-12     Completed Date:  1994-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-85     Citation Subset:  IM    
Affiliation:
Centre of Industrial Hygiene and Occupational Diseases, National Institute of Public Health, Prague, Czechoslovakia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Air Pollutants / analysis,  toxicity*
Animals
Environmental Exposure
Female
Male
Maximum Allowable Concentration
Mice
Nervous System / drug effects*
Nervous System Physiological Phenomena
Predictive Value of Tests
Rats
Rats, Wistar
Solvents / analysis,  toxicity*
Time Factors
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Proteinuria as a biomarker: risk of subsequent morbidity and mortality.
Next Document:  Ozone effects on mechanics and arachidonic acid metabolite concentrations in isolated rat lungs.