Document Detail

Relative acute neurotoxicity of solvents: isoeffective air concentrations of 48 compounds evaluated in rats and mice.
MedLine Citation:
PMID:  8055839     Owner:  NLM     Status:  MEDLINE    
Effect-air concentration regressions of 48 common solvents (aromatic, aliphatic, and chlorinated hydrocarbons, alcohols, ketones, acetates) were determined for 4-hr inhalation exposures in male rats and for 2-hr exposures in female mice. Inhibition of propagation and maintenance of the electrically evoked seizure discharge was used as a criterion of the acute neurotropic effect. The isoeffective concentrations in air were estimated by interpolation on the level of one-third of the maximum effect (ECC). ECC estimates ranged from 90 to 24,000 ppm and were several times lower than concentrations evoking behavioral inhibition and by one to two orders lower than concentrations inducing narcosis. Correlations between corresponding values in both species were high (r > 0.9), indicating a relative independence of the estimates from experimental conditions. The relative potency estimates had only negligible correlation with octanol:water distribution coefficients or other physicochemical predictors for the whole sample of solvents, but moderate to high correlation (r = 0.5 to 0.9) in homogenous groups of nonpolar solvents, permitting cautious predictions. When applied to known effective concentrations of some solvents on human performance and subjective state, the comparative potency procedure suggests that ceiling and STEL values of some solvents may not reliably protect workers from acute nervous depression.
E Frantík; M Hornychová; M Horváth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  66     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-09-12     Completed Date:  1994-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-85     Citation Subset:  IM    
Centre of Industrial Hygiene and Occupational Diseases, National Institute of Public Health, Prague, Czechoslovakia.
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MeSH Terms
Air Pollutants / analysis,  toxicity*
Environmental Exposure
Maximum Allowable Concentration
Nervous System / drug effects*
Nervous System Physiological Phenomena
Predictive Value of Tests
Rats, Wistar
Solvents / analysis,  toxicity*
Time Factors
Reg. No./Substance:
0/Air Pollutants; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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