Document Detail


Relative activity of N-(beta-D-glucopyranosyl)nicotinic acid to nicotinic acid as a niacin nutrient in rats and in Lactobacillus plantarum ATCC 8014.
MedLine Citation:
PMID:  9063984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the relative activity of N-(beta-D-glucopyranosyl)-nicotinic acid as a niacin nutrient in rats and in Lactobacillus plantarum ATCC 8014. N-(beta-D-Glucopyranosyl)-nicotinic acid is a detoxified product or storage form of nicotinic acid that is found in plants. The relative activity of N-(beta-D-glucopyranosyl)nicotinic acid to nicotinic acid in rats was 1/2.3, 1/2.2, 1/1.0, and 1/1.7 as indices of the body weight gain, food intake, blood NAD content, and the increased urinary excretion of niacin and its metabolites, respectively. N-(beta-D-Glucopyranosyl)nicotinic acid had no niacin activity in Lactobacillus plantarum ATCC 8014.
Authors:
H Nishitani; H Taguchi; M Yonezima; K Shibata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  60     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  333-4     Citation Subset:  B    
Affiliation:
R&D Center, Terumo Corporation, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Glucose / analogs & derivatives*,  metabolism,  pharmacology
Lactobacillus / metabolism*
Male
NAD / blood
Niacin / metabolism,  pharmacology*
Niacinamide / analogs & derivatives,  urine
Nicotinic Acids / metabolism,  pharmacology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/N-glucopyranosylnicotinic acid; 0/Nicotinic Acids; 50-99-7/Glucose; 53-84-9/NAD; 59-67-6/Niacin; 701-44-0/N'-methyl-2-pyridone-5-carboxamide; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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