Document Detail

Relative acidity scale of bile acids through ESI-MS measurements.
MedLine Citation:
PMID:  20556307     Owner:  NLM     Status:  MEDLINE    
The anion proton affinity of the most important human bile acids and those of the corresponding keto bile acids have been examined in order to establish a true (intrinsic) relative acidity scale. The measurements have been carried out in the gas-phase using the Cooks' kinetic method. The remarkably high acidity of cholic acid with respect to the other bile acids was confirmed. Rationalization of the differences found for the various acids and comparisons with the available solution-phase data are discussed with the help of theoretical calculations.
Olga Bortolini; Giancarlo Fantin; Valeria Ferretti; Marco Fogagnolo; Pier Paolo Giovannini; Alessandro Medici
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-17
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  8     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3674-7     Citation Subset:  IM    
Dipartimento di Chimica, Università della Calabria, Via Bucci 12 C, 87036 Rende (CS), Italy.
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MeSH Terms
Bile Acids and Salts / chemistry*
Gas Chromatography-Mass Spectrometry
Hydrogen Bonding
Hydrogen-Ion Concentration
Models, Molecular
Molecular Conformation
Spectrometry, Mass, Electrospray Ionization
Tandem Mass Spectrometry
Reg. No./Substance:
0/Bile Acids and Salts

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