Document Detail

Relative ability of full and partial forced expiratory maneuvers to identify diminished airway function in infants with cystic fibrosis.
MedLine Citation:
PMID:  12421744     Owner:  NLM     Status:  MEDLINE    
The tidal and raised volume rapid thoracoabdominal compression techniques are increasingly used to detect diminished airway function in infancy. The aim of this study was to assess the relative ability of parameters measured by these techniques to identify diminished airway function in infants newly diagnosed with cystic fibrosis (CF) with and without clinical evidence of prior lower respiratory illness. A cross-sectional, prospective study design was used in which maximal flow at functional residual capacity (VmaxFRC) from the tidal technique and FVC, FEV0.5, FEF75, and FEF25-75 from the raised volume technique were measured in 47 infants with CF and 187 healthy infants of similar body size, sex distribution, ethnic group, and exposure to maternal smoking. Multiple linear regression was used to assess group differences and to calculate SD scores for each parameter for the infants with CF. Airway function was also compared with clinical assessments of respiratory status made by pediatric pulmonologists. FEV0.5 was significantly diminished in 13 infants with CF, of whom 4 had been identified by clinicians as having normal respiratory status. Only one infant with CF had a VmaxFRC below the estimated normal range. Airway function is diminished in infants with CF irrespective of prior lower respiratory illness and in those whose respiratory status is considered normal by pediatric pulmonologists. In infants with CF, the raised volume technique identified diminished airway function more frequently than the tidal technique.
Sarath C Ranganathan; Andrew Bush; Carol Dezateux; Siobhan B Carr; Ah-Fong Hoo; Sooky Lum; Su Madge; John Price; John Stroobant; Angie Wade; Colin Wallis; Hilary Wyatt; Janet Stocks
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  166     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2003-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1350-7     Citation Subset:  AIM; IM    
Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health, London, United Kingdom.
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MeSH Terms
Age Factors
Child Welfare
Child, Preschool
Cystic Fibrosis / complications,  microbiology,  physiopathology*
Forced Expiratory Flow Rates / physiology*
Forced Expiratory Volume / physiology*
Functional Residual Capacity / physiology
Infant Welfare
Infant, Newborn
Respiratory Function Tests
Respiratory Tract Infections / complications,  microbiology,  physiopathology
Vital Capacity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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