| Relative telomere length and cognitive decline in the Nurses' Health Study. | |
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MedLine Citation:
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PMID: 21295115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomeres are short DNA repeats on the ends of mammalian chromosomes, which can undergo incomplete replication leading to gradual shortening with each cell cycle. Age and oxidative stress are contributors to telomere shortening; thus, telomere length may be a composite measure of biologic aging, and a potential predictor of health status in older adults. We evaluated whether relative telomere length (the proportion of telomere repeat copy number to single gene copy number, using a real-time PCR method) predicts cognitive decline measured ten years later among ∼ 2000 older participants in the Nurses' Health Study (NHS). Mixed linear regression was used to evaluate mean differences in cognitive decline according to telomere length. After adjustment for potential confounders, we found that decreasing telomere length was associated with more cognitive decline, although associations were modest (e.g. for a global score, averaging all six tests in our cognitive battery, mean difference=0.03 standard units per SD increase in telomere length; p=0.04). The magnitude of these estimates was similar to the differences we find in this cohort for women one year apart in age (e.g. the differences that we observe between women who are 73 versus 74 years of age); thus, our results suggest that telomere length is not a particularly powerful marker of impending cognitive decline. |
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Authors:
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Elizabeth E Devore; Jennifer Prescott; Immaculata De Vivo; Francine Grodstein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-02 |
Journal Detail:
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Title: Neuroscience letters Volume: 492 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-28 Completed Date: 2011-06-21 Revised Date: 2013-03-20 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 15-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. nheed@channing.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / genetics*, metabolism*, psychology* Cognition Disorders / genetics* Female Gene Dosage Health Surveys Humans Middle Aged Telomere / metabolism, ultrastructure* |
| Grant Support | |
ID/Acronym/Agency:
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AG15424/AG/NIA NIH HHS; CA40356/CA/NCI NIH HHS; F32 AG031633/AG/NIA NIH HHS; F32 AG031633/AG/NIA NIH HHS; F32 AG031633-03/AG/NIA NIH HHS; R01 AG015424-01A1/AG/NIA NIH HHS; R01 CA040356-15/CA/NCI NIH HHS |
| Comments/Corrections | |
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