Document Detail

The relative atrial index (RAI)--a novel, simple, reliable, and robust transthoracic echocardiographic indicator of atrial defects.
MedLine Citation:
PMID:  20097528     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The detection of atrial septal defects (ASDs) and other shunts is sometimes difficult on transthoracic echocardiography. In addition, the quantitative assessment of right-heart volume loading as an indicator of significant shunting can be difficult, with subjective estimation commonly used. Thus, the initial aim of this study was to test the accuracy of a simple, noninvasive index using atrial area dimensions to detect the presence of an ASD. Subsequently, the index was used to assess the degree of normalization and remodeling of atrial size following percutaneous ASD device closure. METHODS: The relative atrial index (RAI) was derived from standard apical 4-chamber views as right atrial area divided by left atrial area. RAI was calculated in patients with previously diagnosed secundum atrial defects (n=219) with no concomitant lesions and then compared with those calculated in age-matched controls (n=219). 101 of the 219 patients with secundum atrial defects underwent percutaneous device closure. Measurements were obtained before and 1 day after percutaneous closure as well as in the early (mean, 124 days) and late (mean, 390 days) stages of follow-up. RESULTS: The mean RAI in patients with ASDs (1.23+/-0.23) was significantly higher than that in the age-matched normal control group (0.78+/-0.1) (P<.0001). The mean RAI in patients with ASD was also significantly higher than that in the general population (0.81+/-0.15) (P<.0001). Receiver operating characteristic curve analysis suggested that a nominal RAI cutoff value of >0.92 predicted patients with ASDs versus matched controls with 99.1% sensitivity and 90.5% specificity. After percutaneous closure, significant atrial remodeling occurred immediately, with a reduction in the mean RAI at day 1 to 0.93+/-0.16 (P<.0001) and complete normalization at early follow-up to 0.81+/-0.12. CONCLUSION: The RAI, a novel and simple transthoracic parameter, reliably identifies patients with possible atrial shunting. The resolution of right atrial enlargement occurs remarkably early after percutaneous ASD closure, as demonstrated by this novel parameter.
Natalie F A Kelly; Darren L Walters; Lisa A Hourigan; Darryl J Burstow; Gregory M Scalia
Related Documents :
3289808 - Sensitivity and specificity of programmed atrial stimulation for induction of supravent...
18094348 - Quality of anticoagulation monitoring in nonvalvular atrial fibrillation patients: comp...
1987258 - Ostium secundum atrial septal defect in the elderly.
17885518 - Prevalence of paroxysmal atrial fibrillation in brugada syndrome: a case series and a r...
21736598 - Increased lymphatic vessel density and lymphangiogenesis in inflammatory bowel disease.
3793238 - Brucella arthritis in children.
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-01-25
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  23     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  IM    
Copyright Information:
Crown Copyright (c) 2010. Published by Mosby, Inc. All rights reserved.
The Prince Charles Hospital, Cardiac Sciences Unit, Echocardiography Lab, Chermside, Queensland, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Echocardiography / methods*
Heart Atria / ultrasonography*
Heart Septal Defects, Atrial / ultrasonography*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Reproducibility of Results
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ventricular Rotation Is Independent of Cardiac Looping: A Study in Mice With Situs Inversus Totalis ...
Next Document:  Normal Rotational, Torsion and Untwisting Data in Children, Adolescents and Young Adults.