Document Detail


Relationships of ultrasonic backscatter with ultrasonic attenuation, sound speed and bone mineral density in human calcaneus.
MedLine Citation:
PMID:  11120369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrasonic attenuation and sound speed have been investigated in trabecular bone by numerous authors. Ultrasonic backscatter has received much less attention. To investigate relationships among these three ultrasonic parameters and bone mineral density (BMD), 30 defatted human calcanei were investigated in vitro. Normalized broadband ultrasonic attenuation (nBUA), sound speed (SOS), and logarithm of ultrasonic backscatter coefficient (LBC) were measured. Bone mineral density was assessed using single-beam dual energy x-ray absorptiometry (DEXA). The correlation coefficients of least squares linear regressions of the three individual ultrasound (US) parameters with BMD were 0.84 (nBUA), 0.84 (SOS) and 0.79 (LBC). The 95% confidence intervals for the correlation coefficients were 0. 69-0.92 (nBUA), 0.68-0.92 (SOS) and 0.60-0.90 (LBC). The correlations among pairs of US variables ranged from 0.63-0.79. Variations in nBUA accounted for r(2) = 62% of the variations in LBC. Variations in SOS accounted for r(2) = 40% of the variations in LBC. These results suggest that ultrasonic backscattering properties may contain substantial information not already contained in nBUA and SOS. A multiple regression model including all three US variables was somewhat more predictive of BMD than a model including only nBUA and SOS.
Authors:
K A Wear; A P Stuber; J C Reynolds
Related Documents :
12665639 - Densitometric diagnosis of osteoporosis in men: effect of measurement site and normativ...
3686229 - Relationship between kyphosis, scoliosis, and osteoporosis in the elderly population.
16007329 - Amelioration of osteoporosis and hypovitaminosis d by sunlight exposure in hospitalized...
9545479 - Lateral femoral scan: an alternative method for assessing bone mineral density in child...
22644889 - Body composition and skeletal health: too heavy? too thin?
17676429 - A 2-year prospective study of bone metabolism and bone mineral density in adolescents w...
21397739 - Greater tissue mineralization heterogeneity in femoral neck cortex from hip-fractured f...
20691919 - The effect of variable waveform low-intensity pulsed ultrasound in a fourth metacarpal ...
23124609 - Difference in subchondral cancellous bone between postmenopausal women with hip osteoar...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  26     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-22     Completed Date:  2001-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1311-6     Citation Subset:  IM    
Affiliation:
U.S. Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD, USA. kaw@cdrh.fda.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Bone Density*
Calcaneus / metabolism,  ultrasonography*
Humans
Ultrasonics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vitro validation of volumetric blood flow measurement using Doppler flow wire.
Next Document:  Comparative sensitivity of human and bovine erythrocytes to sonolysis by 1-MHz ultrasound.