| Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets. | |
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MedLine Citation:
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PMID: 7637648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These studies were conducted to determine relationships of plasma low-density lipoprotein (LDL) cholesterol concentrations and hepatic mRNA levels for apolipoprotein (apo) B, LDL receptor, and hepatic hydroxymethyl glutaryl coenzyme A (HMG CoA) synthase with plasma LDL apo B production and catabolic rates in baboons maintained on a low-cholesterol, low-fat chow diet and on a high-cholesterol, high-fat (HCHF) diet. Twelve baboons with LDL cholesterol levels ranging from low to high on the HCHF diet but with similar high-density lipoprotein (HDL) cholesterol levels were selected from a colony of selectively bred pedigreed baboons. LDL apo B turnover and hepatic mRNA concentrations for apo B, LDL receptor, and HMG CoA synthase were measured on a chow diet and again on a HCHF diet fed for 14 weeks. LDL apo B fractional catabolic rates decreased and production rates increased on the HCHF diet. Hepatic mRNA concentrations for apo B were not affected by the HCHF diet. Hepatic LDL receptor and HMG CoA synthase mRNA concentrations decreased on the HCHF diet as compared with the chow diet. LDL apo B fractional catabolic rate was negatively correlated with plasma cholesterol, LDL cholesterol, LDL apo B, and LDL apo B production and positively correlated with hepatic LDL receptor and HMG CoA synthase mRNA concentrations and with plasma LDL triglyceride to cholesterol ratio on the chow diet but not on the HCHF diet. LDL apo B production was positively correlated with plasma cholesterol, LDL cholesterol, and LDL apo B on the HCHF diet and negatively correlated with LDL triglyceride to cholesterol ratio on both chow and HCHF diets.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R S Kushwaha; P H Barrett; C A Reardon; D S Lewis; K D Carey; G S Getz; H C McGill |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 44 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-12 Completed Date: 1995-09-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1058-66 Citation Subset: IM |
Affiliation:
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Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoproteins B / blood*, genetics, metabolism Cholesterol, Dietary / administration & dosage Cholesterol, LDL / blood Diet, Fat-Restricted / veterinary* Dietary Fats / administration & dosage* Female Hydroxymethylglutaryl-CoA Synthase / analysis, genetics, physiology Lipoproteins, LDL / blood*, metabolism Liver / chemistry, enzymology Male Papio / metabolism* RNA, Messenger / analysis, genetics Receptors, LDL / analysis, genetics Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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HL28972/HL/NHLBI NIH HHS; HL41256/HL/NHLBI NIH HHS; RR02176/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Cholesterol, Dietary; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Lipoproteins, LDL; 0/RNA, Messenger; 0/Receptors, LDL; 0/Triglycerides; EC 2.3.3.10/Hydroxymethylglutaryl-CoA Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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