Document Detail

Relationships of osteoprotegerin with albuminuria and asymmetric dimethylarginine in essential hypertension: integrating vascular dysfunction.
MedLine Citation:
PMID:  22136618     Owner:  NLM     Status:  Publisher    
Objectives: To investigate the inter-relationships of osteoprotegerin (OPG) with albumin to creatinine ratio (ACR) and asymmetric dimethylargine (ADMA) in hypertensive patients. Methods: In 198 untreated non-diabetic hypertensive patients [130 males, mean age = 51.5 years, office blood pressure (BP) = 152/98 mmHg] ACR values and OPG and ADMA levels were determined. Results: Based on the median value of OPG distribution (5.03 pmol/l) patients with high (n = 101) compared with those with low OPG values (n = 97) had greater 24-h systolic BP (152 ± 5 versus 137 ± 7 mmHg, p < 0.0001), ACR [25.3 (5 - 190) versus 17.3 (5 - 92) mg/g, p = 0.003) and ADMA [0.62 (0.58 - 0.68) versus 0.57 (0.48 - 0.62) μmol/l, p = 0.001), independently of confounding factors. Multiple regression analyses revealed that ADMA (b = 0.388, p < 0.0001), 24-h systolic BP (b = 0.228, p = 0.01) and ACR (b = 0.470, p < 0.0001) were independent predictors of OPG (R(2) = 0.398, p < 0.0001). Conclusions: In hypertensive patients, high OPG levels are accompanied by pronounced albuminuria and endothelial dysfunction, as reflected by raised ADMA levels. Furthermore, the independent associations of OPG with ACR and ADMA, suggests a link between OPG and the progression of diffuse hypertensive vascular damage.
Costas Tsioufis; Athanasios Aggelis; Kyriakos Dimitriadis; Costas Thomopoulos; Alexandros Kasiakogias; Vanessa Tzamou; Stella-Maria Kyvelou; Dimitri P Mikhailidis; Vasilios Papademetriou; Christodoulos Stefanadis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-3
Journal Detail:
Title:  Expert opinion on therapeutic targets     Volume:  -     ISSN:  1744-7631     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101127833     Medline TA:  Expert Opin Ther Targets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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