Document Detail

Relationships of night/day heart rate ratio with carotid intima media thickness and markers of arterial stiffness.
MedLine Citation:
PMID:  21514590     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To analyze the relationship between office and ambulatory heart rate, and its variability, and arterial stiffness in patients with primary arterial hypertension. METHODS: A cross-sectional study was conducted in a primary care setting, with the inclusion of 356 hypertensive patients aged 30-80 years. Office and ambulatory blood pressure, heart rate, night/day heart rate ratio and the corresponding standard deviations, were determined. Arterial stiffness was assessed according to carotid intima media thickness, pulse wave velocity, the central and peripheral augmentation index, and the ambulatory arterial stiffness index. RESULTS: Carotid intima media thickness, central and peripheral augmentation index, and ambulatory arterial stiffness index were negatively correlated to office and ambulatory heart rate and its standard deviation, and positively correlated to the night/day heart rate ratio. Pulse wave velocity showed a negative correlation to 24h standard deviation heart rate and a positive correlation to nocturnal heart rate and the night/day heart rate ratio. For each 10bpm increment in 24h heart rate, the pulse wave velocity increased 0.42m/s (95%CI: 0.23-0.60) and ambulatory arterial stiffness index decreased 0.01 (95%CI: 0.01-0.02); in the case of office heart rate, the peripheral augmentation index decreased 4.74 (95%CI: 3.15-6.33) and central augmentation index decreased 3.52 (95%CI: 2.43-4.30), while for 24h standard deviation heart rate, carotid intima media thickness decreased 0.03mm (95%CI: 0.01-0.06). CONCLUSIONS: Office and ambulatory heart rate, and the corresponding standard deviations, are inversely associated to the arterial stiffness markers, with the exception of pulse wave velocity, where a direct correlation is observed. A greater increase in night/day ratio, i.e., a lesser decrease in nocturnal heart rate, is associated to increased arterial stiffness.
Luis García-Ortiz; Angel García-García; Emilio Ramos-Delgado; María C Patino-Alonso; Jose I Recio-Rodríguez; Emiliano Rodríguez-Sánchez; Manuel A Gómez-Marcos
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-5
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Primary Care Research Unit, La Alamedilla, Salamanca, Spain.
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