Document Detail

Relationships between vitamin D, parathyroid hormone and bone mineral density in inflammatory bowel disease.
MedLine Citation:
PMID:  8568480     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To explore the relationships between vitamin D intake, serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (250HD) concentrations, and bone mineral density (BMD) in inflammatory bowel disease (IBD). SETTING: A university hospital clinic in Finland. SUBJECTS: One hundred and fifty randomly selected patients with IBD from the hospital register and 73 healthy controls. MEASUREMENTS: BMD of the lumbar spine and the proximal femur was measured with dual energy X-ray absorptiometry. Vitamin D intake and serum levels of 250HD and PTH were determined. RESULTS: The IBD patients had a lower serum 250HD concentration (28.4 [SD 12.0] nmol L-1) than the controls (36.1 [16.7] nmol L-1; P = 0.001), whereas no differences in the vitamin D intake or the serum PTH levels were found. The serum 250HD concentrations and the vitamin D intake of the patients with ulcerative colitis (n = 67) were similar to those of the Crohn's disease patients (n = 76). The patients with Crohn's disease of the small bowel had slightly, but not significantly, lower serum 250HD concentrations (25.6 [11.0] nmol L-1) than the other Crohn's disease patients (31.4 [14.3] nmol L-1; P = 0.061). In the IBD patients, the vitamin D intake and the serum 250HD and PTH concentrations were not associated with BMD. CONCLUSIONS: Patients with IBD have lower serum levels of 250HD than healthy controls, but similar serum PTH concentrations and vitamin D intake. Vitamin D intake, and the serum levels of 250HD and PTH are not associated with BMD, and malabsorption is unlikely to be a major factor in the aetiology of bone loss in unselected IBD patients.
J Silvennoinen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  239     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-03-05     Completed Date:  1996-03-05     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
Department of Internal Medicine, University of Oulu, Finland.
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MeSH Terms
Bone Density*
Case-Control Studies
Colitis, Ulcerative / blood,  physiopathology
Crohn Disease / blood,  physiopathology
Hydroxycholecalciferols / blood*
Inflammatory Bowel Diseases / blood*,  physiopathology*
Parathyroid Hormone / blood*
Vitamin D / administration & dosage*
Reg. No./Substance:
0/Hydroxycholecalciferols; 0/Parathyroid Hormone; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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