Document Detail

Relationships between telocytes and cardiomyocytes during pre- and post-natal life.
MedLine Citation:
PMID:  20455994     Owner:  NLM     Status:  MEDLINE    
Evidence has been given that the adult heart contains a specific population of stromal cells lying in close spatial relationship with cardiomyocytes and with cardiac stem cells in sub-epicardial cardiogenic niches. Recently termed 'telocytes' because of their long cytoplasmic processes embracing the parenchymal cells, these cells have been postulated to be involved in heart morphogenesis. In our opinion, investigating the occurrence and morphology of telocytes during heart histogenesis may shed further light on this issue. Our findings show that typical telocytes are present in the mouse heart by early embryonic to adult life. These cells closely embrace the growing cardiomyocytes with their long, slender cytoplasmic processes. Hence, in the developing myocardium, telocytes may play nursing and guiding roles for myocardial precursors to form the correct three-dimensional tissue architectural pattern, as previously suggested.
Maria-Simonetta Faussone-Pellegrini; D Bani
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Publication Detail:
Type:  Journal Article     Date:  2010-04-23
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  14     ISSN:  1582-4934     ISO Abbreviation:  J. Cell. Mol. Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1061-3     Citation Subset:  IM    
Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy.
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MeSH Terms
Animals, Newborn
Embryo, Mammalian / cytology,  metabolism
Myocardium / cytology*,  ultrastructure
Myocytes, Cardiac / cytology*,  metabolism,  ultrastructure

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