| Relationships between sodium clearance, plasma renin activity, plasma aldosterone, renal hemodynamics and blood pressure in essential hypertension. | |
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MedLine Citation:
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PMID: 7000463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal hemodynamics, plasma renin activity (PRA), plasma aldosterone (PA) and sodium excretion were studied in essential hypertension. PAH clearance (CPAH) and glomerular filtration rate (GFR) were normal or increased in early hypertension and depressed at later stages, especially in malignant cases. The PAH extraction ratio was depressed only in patients with low CPAH values. CPAH did not correlate inversely with blood pressure in benign hypertension. Later reexamination of untreated patients revealed a decrease in CPAH, but no further increase in blood pressure. Antihypertensive treatment prevented the decrease in CPAH. Patients with essential hypertension showed no abnormality in basal sodium excretion, plasma aldosterone, plasma renin activity and the sodium:aldosterone relationship. Basal sodium clearance did not correlate with GFR and the fractional sodium excretion was not pressure-dependent. When clearance determinations and measurements of PA and PRA were performed simultaneously under standardized conditions, PA and PRA were correlated inversely with CPAH and GFR. There was no relationship between PA or PRA and the blood pressure. Unless a defective release of renal prostaglandins and/or kinins could be shown to be responsible for the increase in systemic blood pressure, there is no evidence for a primary renal disturbance in essential hypertension. |
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Authors:
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F C Reubi; P Weidmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension Volume: 2 ISSN: 0148-3927 ISO Abbreviation: Clin Exp Hypertens Publication Date: 1980 |
Date Detail:
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Created Date: 1981-01-16 Completed Date: 1981-01-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7803060 Medline TA: Clin Exp Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 593-612 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood* Glomerular Filtration Rate Humans Hypertension / physiopathology* Hypertension, Malignant / physiopathology Kidney / blood supply, physiopathology* Renin / blood* Sodium / metabolism* p-Aminohippuric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 61-78-9/p-Aminohippuric Acid; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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