Document Detail

Relationships between serum adiponectin, leptin concentrations and bone mineral density, and bone biochemical markers in Chinese women.
MedLine Citation:
PMID:  20184866     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adiponectin and leptin, as the main circulating peptides secreted by adipose tissue, are potential contributors to bone metabolism. However, their association with bone mineral density (BMD) is unknown. We investigated whether these serum adipocytokines concentrations are associated with BMD and bone turnover markers.
METHODS: Serum adiponectin, leptin concentrations, bone turnover biochemical markers, and BMD were determined in 265 premenopausal and 336 postmenopausal Chinese women.
RESULTS: In postmenopausal Chinese women, the multiple linear stepwise regression analysis showed that year since menopause, lean mass, estradiol, and adiponectin, but not fat mass, leptin, were independent predictors of BMD in postmenopausal Chinese women. However, in premenopausal Chinese women, adiponectin was not the predictor of BMD. The significant positive correlations between adiponectin and bone-specific alkaline phosphatase (BAP), bone cross-linked N-telopeptides of type I collagen (NTX) were found only in postmenopausal women. Serum BAP, and NTX, but not adiponectin, decreased in response to alendronate therapy.
CONCLUSIONS: Adiponectin was an independent predictor of BMD, and positively correlated with bone turnover biochemical markers in postmenopausal Chinese women, but not premenopausal women. It suggested that adiponectin may exert a negative effect on bone mass by promoting excessive bone resorption associated with bone loss. However, these effects may be mediated by menopausal status.
Nan Wu; Qing-Ping Wang; Hui Li; Xian-Ping Wu; Zhen-Qiu Sun; Xiang-Hang Luo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-02-23
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  411     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-07-27     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  771-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China. [corrected]
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MeSH Terms
Adiponectin / blood
Aged, 80 and over
Alendronate / pharmacology,  therapeutic use
Alkaline Phosphatase / blood
Biological Markers / blood
Blood / drug effects
Body Composition
Body Mass Index
Bone Density*
Bone Remodeling / drug effects
Bone and Bones / metabolism*
Collagen Type I / blood
Double-Blind Method
Estradiol / blood
Leptin / blood*
Middle Aged
Osteoporosis, Postmenopausal / drug therapy
Peptides / blood
Postmenopause / blood,  metabolism
Premenopause / blood,  metabolism
Treatment Outcome
Young Adult
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/Collagen Type I; 0/Leptin; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 50-28-2/Estradiol; 66376-36-1/Alendronate; EC protein, human; EC Phosphatase
Erratum In:
Clin Chim Acta. 2010 Aug 5;411(15-16):1159

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