Document Detail


Relationships between paced QRS duration and left cardiac structures and function.
MedLine Citation:
PMID:  19476117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In patients with congestive heart failure, QRS duration (QRSd) is correlated with left ventricular (LV) ejection fraction (LVEF), ventricular dyssynchrony and patients' prognosis. However, little is known about the relationships between paced QRS duration (pQRSd) to cardiac structures and function and ventricular dyssynchrony in patients with chronic right ventricular apical (RVA) pacing, which were investigated in this study. METHODS: Seventy patients implanted with DDD(R) pacemaker for high- or third-degree atrioventricular block were enrolled to study pQRSd and echocardiographic variables, including aortic root dimension (AO), left atrial dimension (LAD), LV end-systolic dimension (LVDs), LV end-diastolic dimension (LVDd), interventricular septum thickness (IVST), LV posterior wall thickness (LVPWT), LVEF, interventricular mechanical delay (IVMD), systolic asynchrony index (Ts-SD) and septal-to-lateral delay.The relationships between pQRSd and such variables were examined. RESULTS: The pQRSd correlated positively with LVDd (r = 0.3166, P < 0.05), LVDs (r = 0.3741, P < 0.05), LAD (r = 0.5848, P < 0.01), IVST (r = 0.2925, P < 0.05), and negatively with LVEF (r = -0.3037, P < 0.05). No significant correlations were found between pQRSd and AO, LVPWT, IVMD, Ts-SD and septal-to-lateral delay (all P > 0.05). There was no significant correlation between LVEF and IVMD, Ts-SD, septal-to-lateral delay (P > 0.05). However, IVMD, Ts-SD and septal-to-lateral delay were greater in patients with low LVEF than in patients with normal LVEF (P < 0.05). A cut-off value for pQRSd of 180 ms had a sensitivity of 85.71% and a specificity of 66.67% to detect left atrial dilation. CONCLUSION: pQRSd is correlated with left cardiac structures and LV systolic function. pQRSd > or =180 ms indicates left atrial dilation. There is no correlation between pQRSd and ventricular dyssynchrony.
Authors:
Yangang Su; Wenzhi Pan; Xue Gong; Jie Cui; Xianhong Shu; Junbo Ge
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cardiologica     Volume:  64     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  231-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, PR China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrial Function, Left / physiology*
Atrioventricular Block / physiopathology*,  therapy
Cardiac Pacing, Artificial / methods*
Echocardiography, Doppler / methods
Electrocardiography*
Female
Follow-Up Studies
Heart Atria / physiopathology,  ultrasonography*
Heart Conduction System / physiopathology
Heart Rate
Heart Ventricles / physiopathology,  ultrasonography*
Humans
Male
Prognosis
Retrospective Studies
Stroke Volume / physiology
Systole
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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