Document Detail

Relationships between oestrogen-inducible proteins, oestradiol and electrolyte ratio in breast cyst fluid.
MedLine Citation:
PMID:  8481890     Owner:  NLM     Status:  MEDLINE    
Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were found. The concentrations of cathepsin D and oestradiol were significantly higher in the low electrolyte ratio cyst group than in the high electrolyte ratio cyst group. No significant difference was found between pS2 concentrations in the two groups. The significantly higher intracystic concentrations of cathepsin D, a mitogenic lysosomal endopeptidase and oestradiol in the low electrolyte ratio group may partly provide an explanation for the higher risk of breast cancer which has been observed in this group of women.
L C Lai; C Cornell; T W Lennard
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  69     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-03     Completed Date:  1993-06-03     Revised Date:  2004-12-03    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Department of Clinical Biochemistry, Freeman Hospital, Newcastle upon Tyne, UK.
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MeSH Terms
Cathepsin D / analysis*
Cysts / chemistry*
Estradiol / analysis*
Fibrocystic Breast Disease / chemistry*
Muscle Proteins / analysis*
Potassium / analysis
Sodium / analysis
Reg. No./Substance:
0/24 kDa estrogen-induced protein, human; 0/Muscle Proteins; 0/Proteins; 50-28-2/Estradiol; 7440-09-7/Potassium; 7440-23-5/Sodium; EC D

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